{"title":"伴肉瘤变的牙龈腺鳞癌：病例报告与免疫组化研究","authors":"Masashi Okumura , Yu Usami , Katsutoshi Hirose , Kaori Oya , Eiichi Morii , Narikazu Uzawa , Satoru Toyosawa","doi":"10.1016/j.ajoms.2023.11.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Adenosquamous carcinoma<span> (ASC) is a rare variant of squamous cell carcinoma (SCC). It is thought to be more aggressive with poorer prognosis than conventional SCCs. Therefore, accurate preoperative diagnosis is crucial for adequate treatment strategy. In this report, we will present a case of ASC arising in left mandibular </span></span>gingiva of 76-year-old male. Histological examination revealed both SCC component and adenocarcinoma (AdC) component. Also, transition from AdC to short spindle-shaped and pleomorphic cells, which is known as </span>sarcomatoid change, was observed. Immunohistochemical study revealed that SCC component was positive for p40 and negative for </span>Cytokeratin 7<span> (CK7), whereas, AdC component was negative for p40 and positive for CK7. In area with sarcomatoid change, immunohistochemical analysis revealed that negative expression of both CK7 and E-cadherin but positive expression of Vimentin and nuclear Snail/Slug, indicating the possible role of epithelial-mesenchymal transition (EMT) in AdC to sarcomatoid transition.</span></p></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gingival adenosquamous carcinoma with sarcomatous change: A case report with immunohistochemical study\",\"authors\":\"Masashi Okumura , Yu Usami , Katsutoshi Hirose , Kaori Oya , Eiichi Morii , Narikazu Uzawa , Satoru Toyosawa\",\"doi\":\"10.1016/j.ajoms.2023.11.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>Adenosquamous carcinoma<span> (ASC) is a rare variant of squamous cell carcinoma (SCC). It is thought to be more aggressive with poorer prognosis than conventional SCCs. Therefore, accurate preoperative diagnosis is crucial for adequate treatment strategy. In this report, we will present a case of ASC arising in left mandibular </span></span>gingiva of 76-year-old male. Histological examination revealed both SCC component and adenocarcinoma (AdC) component. Also, transition from AdC to short spindle-shaped and pleomorphic cells, which is known as </span>sarcomatoid change, was observed. Immunohistochemical study revealed that SCC component was positive for p40 and negative for </span>Cytokeratin 7<span> (CK7), whereas, AdC component was negative for p40 and positive for CK7. In area with sarcomatoid change, immunohistochemical analysis revealed that negative expression of both CK7 and E-cadherin but positive expression of Vimentin and nuclear Snail/Slug, indicating the possible role of epithelial-mesenchymal transition (EMT) in AdC to sarcomatoid transition.</span></p></div>\",\"PeriodicalId\":45034,\"journal\":{\"name\":\"Journal of Oral and Maxillofacial Surgery Medicine and Pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral and Maxillofacial Surgery Medicine and Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212555823002454\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212555823002454","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Gingival adenosquamous carcinoma with sarcomatous change: A case report with immunohistochemical study
Adenosquamous carcinoma (ASC) is a rare variant of squamous cell carcinoma (SCC). It is thought to be more aggressive with poorer prognosis than conventional SCCs. Therefore, accurate preoperative diagnosis is crucial for adequate treatment strategy. In this report, we will present a case of ASC arising in left mandibular gingiva of 76-year-old male. Histological examination revealed both SCC component and adenocarcinoma (AdC) component. Also, transition from AdC to short spindle-shaped and pleomorphic cells, which is known as sarcomatoid change, was observed. Immunohistochemical study revealed that SCC component was positive for p40 and negative for Cytokeratin 7 (CK7), whereas, AdC component was negative for p40 and positive for CK7. In area with sarcomatoid change, immunohistochemical analysis revealed that negative expression of both CK7 and E-cadherin but positive expression of Vimentin and nuclear Snail/Slug, indicating the possible role of epithelial-mesenchymal transition (EMT) in AdC to sarcomatoid transition.
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