基于体素的剂量法预测接受90Y玻璃微球放射栓塞的肝癌患者的肝毒性

IF 1 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuklearmedizin-nuclear Medicine Pub Date : 2023-03-30 DOI:10.1055/s-0043-1766312

M. Watanabe, H. Grafe, J. Theysohn, B. Schaarschmidt, J. Ludwig, L. Jochheim, M. Jeschke, H. Schmidt, W. P. Fendler, A. Moraitis, K. Herrmann, K. L. Pomykala, M. Weber

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引用次数: 0

摘要

个体化剂量测定有望改善肝细胞癌(HCC)患者的放射栓塞治疗效果。为此，通过计算全肝正常组织平均剂量(WLNT)来评估健康肝组织(HLT)的耐受剂量，忽略了剂量分布的不均匀性。因此，我们分析了基于体素的剂量学是否可以更准确地预测接受放射栓塞治疗的HCC患者的肝毒性。

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Voxel-based dosimetry predicts hepatotoxicity in hepatocellular carcinoma patients undergoing radioembolization with 90Y glass microspheres

Ziel/Aim Personalized dosimetry holds promise to improve radioembolization treatment outcomes in hepatocellular carcinoma (HCC) patients. To this end, tolerance doses for healthy liver tissue (HLT) are assessed by calculating the mean whole-liver normal tissue dose (WLNT), which neglects non-uniform dose distribution. Thus, we analyzed whether voxel-based dosimetry could be more accurate in predicting hepatotoxicity in HCC patients undergoing radioembolization.

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来源期刊

Nuklearmedizin-nuclear Medicine 医学-核医学

CiteScore

1.70

自引率

13.30%

发文量

267

审稿时长

>12 weeks

期刊介绍： Als Standes- und Fachorgan (Organ von Deutscher Gesellschaft für Nuklearmedizin (DGN), Österreichischer Gesellschaft für Nuklearmedizin und Molekulare Bildgebung (ÖGN), Schweizerischer Gesellschaft für Nuklearmedizin (SGNM, SSNM)) von hohem wissenschaftlichen Anspruch befasst sich die CME-zertifizierte Nuklearmedizin/ NuclearMedicine mit Diagnostik und Therapie in der Nuklearmedizin und dem Strahlenschutz: Originalien, Übersichtsarbeiten, Referate und Kongressberichte stellen aktuelle Themen der Diagnose und Therapie dar. Ausführliche Berichte aus den DGN-Arbeitskreisen, Nachrichten aus Forschung und Industrie sowie Beschreibungen innovativer technischer Geräte, Einrichtungen und Systeme runden das Konzept ab. Die Abstracts der Jahrestagungen dreier europäischer Fachgesellschaften sind Bestandteil der Kongressausgaben. Nuklearmedizin erscheint regelmäßig mit sechs Ausgaben pro Jahr und richtet sich vor allem an Nuklearmediziner, Radiologen, Strahlentherapeuten, Medizinphysiker und Radiopharmazeuten.