单克隆抗体(Mabs)或Janus激酶(Nibs)消融治疗炎症和其他疾病增加感染风险

IF 0.4 Q4 INFECTIOUS DISEASES

Infectious Diseases in Clinical Practice Pub Date : 2023-10-23 DOI:10.1097/ipc.0000000000001317

Eric Santana, Ken S. Rosenthal

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引用次数: 0

摘要

单克隆抗体(mabs)和小分子Janus激酶(JAK)抑制剂(nibs)可用于治疗炎症性疾病、自身免疫性疾病和肿瘤，特别是白血病。这些药物抑制或消耗细胞因子或细胞可导致对某些微生物感染的重要保护丧失。结核病、乙型和丙型肝炎以及带状疱疹的复发对免疫衰竭特别敏感。这些药物抑制细胞因子、分子、途径和细胞的后果被描述、描绘和制表。

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Ablative Treatment of Inflammatory and Other Diseases With Monoclonal Antibodies (Mabs) or Janus Kinases (Nibs) Increases Risk for Infection

Abstract Monoclonal antibodies (mabs) and small molecule Janus kinase (JAK) inhibitors (nibs) are useful for treating inflammatory disease, autoimmune disease, and tumors, especially leukemia. Inhibition or depletion of the cytokines or cells with these drugs can result in loss of important protection against certain microbial infections. Recurrences of tuberculosis, hepatitis B and C, and zoster are especially sensitive to immune depletion. The consequences of inhibition of cytokines, molecules, pathways and cells by these drugs are described, depicted, and tabulated.

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来源期刊

Infectious Diseases in Clinical Practice INFECTIOUS DISEASES-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Medical professionals seeking an infectious diseases journal with true clinical value need look no further than Infectious Diseases in Clinical Practice. Here, clinicians can get full coverage consolidated into one resource, with pertinent new developments presented in a way that makes them easy to apply to patient care. From HIV care delivery to Hepatitis C virus testing…travel and tropical medicine…and infection surveillance, prevention, and control, Infectious Diseases in Clinical Practice delivers the vital information needed to optimally prevent and treat infectious diseases. Indexed/abstracted in: EMBASE, SCOPUS, Current Contents/Clinical Medicine