The effectiveness of resveratrol in the management of childhood obesity

Our review is focused on examining whether or not resveratrol is effective in managing and treating childhood obesity based on its beneficial health effects, while also discussing the progress made in developing functional food products containing resveratrol. Resveratrol is a natural phenolic compound found in the Veratrum grandiflorum and is known for its antioxidant properties. Resveratrol can be found in various foods like berries, grapes, pistachios, dark chocolate, peanut skins, soybeans, and pomegranates. Studies evaluating the effectiveness of resveratrol in the management and treatment of childhood obesity have been conducted both in animals and humans. Through numerous mechanisms, such as activation of AMPK, increasing lipolysis, decreasing leptin levels and leptin/soluble leptin receptor (sOB-R) ratio, managing embryonic oxidative stress biomarkers, and reducing body weight and adiposity in offspring, resveratrol has been shown to be effective in ameliorating symptoms of obesity. Thus far, researchers have established both a goal to be accomplished (treatment and management of childhood obesity) and a bioactive compound (resveratrol) to accomplish that goal, as well as appropriate dosages and times of consumption for preclinical trials, mechanisms of action, and relevant biomarkers of resveratrol. These findings have been used to conduct various preclinical trials to test the efficacy and safety of resveratrol both in vivo and on animals. To our knowledge, the following steps have not yet been completed and are required for future research; 1) clinical trials involving resveratrol supplementation to establish safety, appropriate dosage, and time of consumption in humans, 2) creation of a specialized label for resveratrol functional food products, 3) publications submitted to open access, peer-reviewed journals, 4) approval by a reliable governmental agency, 5) official establishment of the product, and 6) epidemiological studies and after-market research conducted following release of the functional food product to the general public.Keywords: Resveratrol, Obesity, Childhood, Maternal, Cardiovascular, Diabetes, Inflammation.Graphical Abstract: Effects of resveratrol on managing childhood obesity