葛根素治疗糖尿病骨质疏松的网络药理学机制分析

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Yuwei Chen, Qiyuan Sun
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引用次数: 0

摘要

葛根素可促进成骨细胞增殖,也可作为支架材料,但其作用机制尚不清楚。在本研究中,我们探讨了葛根素治疗糖尿病骨质疏松症的主要分子机制。我们利用中药系统药理学数据库和分析平台、PubChem、基于web的基因集分析工具包、cytoscape等筛选葛根素的药物靶点和糖尿病骨质疏松症的疾病靶点。基于蛋白-蛋白互作共表达网络、基因本体、京都基因与基因组富集百科全书等,通过AutoDock进行分子对接,分析葛根素的作用机制。《京都基因基因组百科全书》中富集的主要信号通路为非小细胞肺癌、内分泌抵抗等。主要富集的生物过程有细胞迁移的正向调节、细胞因子介导的信号通路等。细胞成分中主要富集的细胞成分为整合素复合物、血小板α颗粒膜等。分子功能的主要细胞功能有C-X3-C趋化因子结合、一氧化氮合酶调节活性等。肿瘤坏死因子、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基α和前列腺素内过氧化物合成酶2与葛根素对接结合能均小于-5 kcal/mol-1。综上所述,葛根素在糖尿病性骨质疏松中可能通过多靶点、多途径起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Puerarin’s Mechanism in Treating Diabetic Osteoporosis by using Network Pharmacology
Puerarin can promote the proliferation of osteoblasts and it can also be used as a scaffold material, but its mechanism is unknown. In this study, we explored the primary molecular mechanism of puerarin in diabetic osteoporosis treatment. We used traditional Chinese medicine systems pharmacology database and analysis platform, PubChem, web-based gene set analysis toolkit, cytoscape and so on to screen the drug targets of puerarin and the disease targets of diabetic osteoporosis. We analyzed the puerarin mechanism based on the protein-protein interaction co-expression network, gene ontology, Kyoto encyclopedia of genes and genomes enrichment, etc., and molecular docking by AutoDock. The main enriched signaling pathways in the Kyoto encyclopedia of genes and genomes were non-small cell lung cancer, endocrine resistance and so on. The main enriched biological processes were positive regulation of cell migration, cytokine-mediated signaling pathway and so on. The main enriched cell components of the cellular component were the integrin complex, platelet alpha granule membrane and so on. The main cellular functions of the molecular function were C-X3-C chemokine binding, nitric oxide synthase regulator activity and so on. The tumor necrosis factor, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and prostaglandin-endoperoxide synthase 2 with puerarin docking binding energy were all less than -5 kcal/mol-1. In conclusion puerarin may act through multiple targets and some pathways in diabetic osteoporosis.
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来源期刊
自引率
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审稿时长
2 months
期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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