{"title":"胆汁酸与认知正常老年人白质高强度的关系","authors":"X. K. Xu, Yueqi Zhang, X. J. Lu, Baolin Shi","doi":"10.36468/pharmaceutical-sciences.spl.698","DOIUrl":null,"url":null,"abstract":"This study aimed to detect associations of bile acid profile with white matter hyperintensity and quantify the risk of cerebral small vessel disease with high level of bile acid among cognitively normal individuals. All data were obtained from the patients with Alzheimer’s disease neuroimaging initiative with a 10 y follow-up. Multivariate linear regressions were performed with variable selection using the least absolute shrinkage and selection operator method and the linear mixed model was used to analyze longitudinal relationship between non-zero coefficient variables and white matter hyperintensity volume. Four predictors (age, deoxycholic acid, glucose, total intracranial volume) were identified by least absolute shrinkage and selection operator regression analysis and multivariate linear regressions. Age (p value<0.001, mean difference, 1.03 cm 3 [95 % interval: 1.02, 1.04]) and deoxycholic acid (p value<0.05, mean difference, 1.05 cm 3 [95 % confidence interval: 1.00, 1.10]) were significantly associated with white matter hyperintensity. When divided into two groups by the median deoxycholic acid level (1.38 µM), participants with higher deoxycholic acid levels had a higher white matter hyperintensity volume at the 4 th y than those with lower deoxycholic acid levels (mean difference, 0.1 points [95 % confidence interval: -0.17, -0.03]; p<0.05). We found that increased deoxycholic acid levels may lead to the progression of white matter hyperintensity, which suggest that higher deoxycholic acid burden may play a possible role in the pathogenesis of cerebral small vessel disease in cognitively normal older adults. Besides, the study indicates a possible role for inflammation in the pathogenesis of cerebral small vessel disease.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Bile Acid with White Matter Hyperintensity in Cognitively Normal Older Adults\",\"authors\":\"X. K. Xu, Yueqi Zhang, X. J. Lu, Baolin Shi\",\"doi\":\"10.36468/pharmaceutical-sciences.spl.698\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study aimed to detect associations of bile acid profile with white matter hyperintensity and quantify the risk of cerebral small vessel disease with high level of bile acid among cognitively normal individuals. All data were obtained from the patients with Alzheimer’s disease neuroimaging initiative with a 10 y follow-up. Multivariate linear regressions were performed with variable selection using the least absolute shrinkage and selection operator method and the linear mixed model was used to analyze longitudinal relationship between non-zero coefficient variables and white matter hyperintensity volume. Four predictors (age, deoxycholic acid, glucose, total intracranial volume) were identified by least absolute shrinkage and selection operator regression analysis and multivariate linear regressions. Age (p value<0.001, mean difference, 1.03 cm 3 [95 % interval: 1.02, 1.04]) and deoxycholic acid (p value<0.05, mean difference, 1.05 cm 3 [95 % confidence interval: 1.00, 1.10]) were significantly associated with white matter hyperintensity. When divided into two groups by the median deoxycholic acid level (1.38 µM), participants with higher deoxycholic acid levels had a higher white matter hyperintensity volume at the 4 th y than those with lower deoxycholic acid levels (mean difference, 0.1 points [95 % confidence interval: -0.17, -0.03]; p<0.05). We found that increased deoxycholic acid levels may lead to the progression of white matter hyperintensity, which suggest that higher deoxycholic acid burden may play a possible role in the pathogenesis of cerebral small vessel disease in cognitively normal older adults. Besides, the study indicates a possible role for inflammation in the pathogenesis of cerebral small vessel disease.\",\"PeriodicalId\":13292,\"journal\":{\"name\":\"Indian Journal of Pharmaceutical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36468/pharmaceutical-sciences.spl.698\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36468/pharmaceutical-sciences.spl.698","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Association of Bile Acid with White Matter Hyperintensity in Cognitively Normal Older Adults
This study aimed to detect associations of bile acid profile with white matter hyperintensity and quantify the risk of cerebral small vessel disease with high level of bile acid among cognitively normal individuals. All data were obtained from the patients with Alzheimer’s disease neuroimaging initiative with a 10 y follow-up. Multivariate linear regressions were performed with variable selection using the least absolute shrinkage and selection operator method and the linear mixed model was used to analyze longitudinal relationship between non-zero coefficient variables and white matter hyperintensity volume. Four predictors (age, deoxycholic acid, glucose, total intracranial volume) were identified by least absolute shrinkage and selection operator regression analysis and multivariate linear regressions. Age (p value<0.001, mean difference, 1.03 cm 3 [95 % interval: 1.02, 1.04]) and deoxycholic acid (p value<0.05, mean difference, 1.05 cm 3 [95 % confidence interval: 1.00, 1.10]) were significantly associated with white matter hyperintensity. When divided into two groups by the median deoxycholic acid level (1.38 µM), participants with higher deoxycholic acid levels had a higher white matter hyperintensity volume at the 4 th y than those with lower deoxycholic acid levels (mean difference, 0.1 points [95 % confidence interval: -0.17, -0.03]; p<0.05). We found that increased deoxycholic acid levels may lead to the progression of white matter hyperintensity, which suggest that higher deoxycholic acid burden may play a possible role in the pathogenesis of cerebral small vessel disease in cognitively normal older adults. Besides, the study indicates a possible role for inflammation in the pathogenesis of cerebral small vessel disease.
期刊介绍:
The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.