肠道超声联合血液炎症标志物是评估克罗恩病严重程度的更有效工具:一项初步研究

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Huaying Fang, Jie Liu, Kai Qian, Xuemei Xu, Zhaolong Li, Li Xie, Menghan Sun, Song Wang, Jiaqin Xu, Chaolan Lv, Bo Wang, Weiyong Liu, Gengqing Song, Yue Yu
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Methods. 40 CD patients were reviewed in this retrospective study and were divided into the moderate-severe group ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"> <mi>n</mi> <mo>=</mo> <mn>25</mn> </math> ) and nonmoderate-severe group ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M2\"> <mi>n</mi> <mo>=</mo> <mn>15</mn> </math> ) based on a simplified endoscopic score of Crohn’s disease (SES-CD). Double-balloon enteroscopy/colonoscopy were reviewed by three gastroenterologists. A transabdominal ultrasound was performed by two ultrasound specialists. Blood inflammatory markers were measured from morning samples. Results. In evaluating moderate to severe CD patients, (1) IBUS-SAS had a good predictive effect with an area-under-the-curve (AUC) of 0.855 ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M3\"> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ); (2) IUS key parameters (including BWT, CDS, BWS, and I-fat) yielded good predictive effects with AUC of 0.811, 0.731, 0.724, and 0.747, respectively ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M4\"> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ); (3) blood inflammatory markers (including ESR, CRP, PLR, MLR, and NLR) also had good predictive effects with AUC of 0.771, 0.837, 0.728, 0.743, and 0.775, respectively ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M5\"> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ); (4) IBUS-SAS combined with ESR and CRP exerted the best predictive effect with the highest AUC of 0.912 (95% CI: 0.823-1.000), and the sensitivity and specificity were 88.0% and 80.0%, respectively ( <math xmlns=\"http://www.w3.org/1998/Math/MathML\" id=\"M6\"> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ). 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引用次数: 0

摘要

背景和目的。肠超声(IUS)被认为是一种非照射、无创、耐受性良好、有价值的客观评估克罗恩病(CD)活动的工具。然而,目前还没有被广泛接受的肠道超声评分系统。本研究旨在评估IUS关键参数、国际肠超声活动评分(IBUS-SAS)以及IBUS-SAS联合血液炎症标志物评估CD活动的有效性。方法:在本回顾性研究中,40例CD患者根据克罗恩病简化内镜评分(SES-CD)分为中重度组(n = 25)和非中重度组(n = 15)。双气囊肠镜/结肠镜检查由三位胃肠病学家进行回顾。经腹部超声由两名超声专家进行。从早上的样本中测量血液炎症标志物。结果。在评估中重度CD患者时,(1)IBUS-SAS具有良好的预测效果,曲线下面积(AUC)为0.855 (P <0.001);(2) IUS关键参数(包括BWT、CDS、BWS和I-fat)具有较好的预测效果,AUC分别为0.811、0.731、0.724和0.747 (P <0.001);(3)血液炎症指标(ESR、CRP、PLR、MLR、NLR)也具有较好的预测作用,AUC分别为0.771、0.837、0.728、0.743、0.775 (P <0.001);(4) IBUS-SAS联合ESR、CRP的预测效果最好,AUC最高,为0.912 (95% CI: 0.823 ~ 1.000),敏感性和特异性分别为88.0%和80.0% (P <0.001)。结论。在评估中度至重度疾病活动度的CD患者时,IBUS-SAS联合ESR和CRP是比单独使用IBUS-SAS或单独使用炎症标志物更有效的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intestinal Ultrasound Combined with Blood Inflammatory Markers Is a More Efficient Tool in Evaluating Severity of Crohn’s Disease: A Pilot Study
Background and Aims. Intestinal ultrasound (IUS) is considered a nonirradiating, noninvasive, well-tolerated, and valuable tool for objectively assessing Crohn’s disease (CD) activity. However, there is no widely accepted intestinal ultrasound scoring system. This study is aimed at evaluating the efficacy of IUS key parameters, the International Bowel Ultrasound Activity Score (IBUS-SAS), and IBUS-SAS combined with blood inflammatory markers in assessing CD activity. Methods. 40 CD patients were reviewed in this retrospective study and were divided into the moderate-severe group ( n = 25 ) and nonmoderate-severe group ( n = 15 ) based on a simplified endoscopic score of Crohn’s disease (SES-CD). Double-balloon enteroscopy/colonoscopy were reviewed by three gastroenterologists. A transabdominal ultrasound was performed by two ultrasound specialists. Blood inflammatory markers were measured from morning samples. Results. In evaluating moderate to severe CD patients, (1) IBUS-SAS had a good predictive effect with an area-under-the-curve (AUC) of 0.855 ( P < 0.001 ); (2) IUS key parameters (including BWT, CDS, BWS, and I-fat) yielded good predictive effects with AUC of 0.811, 0.731, 0.724, and 0.747, respectively ( P < 0.001 ); (3) blood inflammatory markers (including ESR, CRP, PLR, MLR, and NLR) also had good predictive effects with AUC of 0.771, 0.837, 0.728, 0.743, and 0.775, respectively ( P < 0.001 ); (4) IBUS-SAS combined with ESR and CRP exerted the best predictive effect with the highest AUC of 0.912 (95% CI: 0.823-1.000), and the sensitivity and specificity were 88.0% and 80.0%, respectively ( P < 0.001 ). Conclusion. IBUS-SAS combined with ESR and CRP is a more efficient tool than IBUS-SAS alone or inflammatory markers alone in evaluating CD patients with moderate to severe disease activity.
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来源期刊
Gastroenterology Research and Practice
Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.40
自引率
0.00%
发文量
91
审稿时长
1 months
期刊介绍: Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.
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