双层纳米微羟基磷灰石对植入Ti-6Al-4V ELI表面特性的影响

IF 1 Q4 ENGINEERING, MECHANICAL
None Ilhamdi, None Gunawarman, None J. Affi, None O. Susanti, None D. Juliadmi, None D. Oktaviana, None M. Tauhid
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引用次数: 1

摘要

Ti-6Al-4V ELI是一种众所周知的、流行的医用级钛合金,因为它具有生物相容性和优异的机械性能。然而,像其他金属种植体一样,它的生物活性较低,影响种植体周围的组织再生,并可能导致种植体失败。因此,生物活性物质如羟基磷灰石(HA)通常被涂覆在金属植入物上以提高其生物活性。然而,据报道,单层透明质酸在人体内长期暴露后会溶解到体液中。本研究采用电泳沉积(EPD)方法,将双层HA沉积在Ti-6Al-4V ELI螺旋型植入体表面。底层是微尺寸的HA,第二层是纳米尺寸的HA。将含有各种微纳米级HA粉末的悬浮液均质1 h,然后用磁力搅拌器超声2 h。涂层层在700℃下烧结1 h,按照适当的手术步骤将双层涂层螺钉植入健康大鼠胫骨近端。一些没有HA沉积的螺钉也被植入黑家鼠体内进行比较。2、3、4周后手术取出植入螺钉,进行光学显微镜、扫描电镜、x射线荧光观察。结果表明:各涂层试样表面均有有机物质存在,螺杆表面有少量HA层崩解;崩解的HA残留在螺钉表面,且随着植入时间的增加,HA的数量增加,说明骨与HA层的骨结合增强。XRF分析表明,涂覆后的螺杆表面Ti和氧化钛含量与未涂覆的螺杆表面Ti和氧化钛含量有显著差异,有HA层的螺杆表面Ti含量仅为0.66% (TiO2含量0.39%),未涂覆的螺杆表面Ti含量为70% (TiO2含量67%)。当螺丝钉暴露在体液中时,TiO2作为一种快速的自愈反应形成,透明质酸作为一个界面来对抗可能含有侵略性离子的体液。因此,HA层不仅可以有效地抵抗腐蚀,还可以抑制种植体表面TiO2的形成。涂覆的螺钉也显示了HA层与种植螺钉表面之间的牢固结合。此外,螺钉表面Ca和P元素的比值在0.58 ~ 2.04之间,在骨特性范围内。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Bilayer Nano-Micro Hydroxyapatite on the Surface Characteristics of Implanted Ti-6Al-4V ELI
Ti-6Al-4V ELI is a well-known, popular medical-grade titanium alloy due to its biocompatibility and excellent mechanical properties. However, like other metal implants, it is less bioactive that affects tissue regeneration around the implant, and may lead to implant failure. So, a bioactive substance such as hydroxyapatite (HA) has usually been coated on metal implants to improve its bioactive properties. However, a single layer of HA was reported to be dissolved into body fluid after a long time of exposure in the human body. In this study, bilayer HA was deposited on the surface of screw-type implants made of Ti-6Al-4V ELI through electrophoretic deposition (EPD method. The bottom layer consists of micro-size of HA, and the second layer contains nano-size HA. The suspension contains each micro and nano size of HA powder was homogenized for 1 h followed by sonication for 2 h using a magnetic stirrer. The coating layer was subsequently sintered at 700oC for 1 h. The bilayer-coated screw implant was then implanted into the proximal tibia of health rattus novergicus under proper surgical procedures. Some screws without HA deposition were also implanted into rattus novergicus for comparison. The implanted screws were then taken out via surgery after 2, 3 and 4 weeks, and they were subsequently observed by optical microscope, SEM and XRF. The results showed that organic material is found on each coated specimen, and few HA layer is disintegrated from the surface of the screw. The disintegrated HA remained in the surface of the screw, and the amount of HA increased with increasing implantation time, which indicates the increase of osseointegration between the bone and HA layer. XRF showed a significant difference in Ti and titanium oxide contents on the surface of the coated samples and the non-coted ones, where it is only 0.66%Ti (0.39% TiO2) on the surface of the screw with HA layer and 70%Ti (67% TiO2) for without HA. When TiO2 is formed as a fast self-healing reaction while the screw is exposed to body fluid, the HA acts as an interface against body fluid that may contain aggressive ions. So, HA layer is not only effective against corrosion attack but also inhibits the formation of TiO2 on the implant surface. The coated screws also revealed a strong bonding between the HA layer and the surface of the implant screw. Besides, the ratio between Ca and P elements on the screw surface is in the range of 0.58 – 2.04, which is in the range of bone characteristics.
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来源期刊
CiteScore
2.40
自引率
10.00%
发文量
43
审稿时长
20 weeks
期刊介绍: The IJAME provides the forum for high-quality research communications and addresses all aspects of original experimental information based on theory and their applications. This journal welcomes all contributions from those who wish to report on new developments in automotive and mechanical engineering fields within the following scopes. -Engine/Emission Technology Automobile Body and Safety- Vehicle Dynamics- Automotive Electronics- Alternative Energy- Energy Conversion- Fuels and Lubricants - Combustion and Reacting Flows- New and Renewable Energy Technologies- Automotive Electrical Systems- Automotive Materials- Automotive Transmission- Automotive Pollution and Control- Vehicle Maintenance- Intelligent Vehicle/Transportation Systems- Fuel Cell, Hybrid, Electrical Vehicle and Other Fields of Automotive Engineering- Engineering Management /TQM- Heat and Mass Transfer- Fluid and Thermal Engineering- CAE/FEA/CAD/CFD- Engineering Mechanics- Modeling and Simulation- Metallurgy/ Materials Engineering- Applied Mechanics- Thermodynamics- Agricultural Machinery and Equipment- Mechatronics- Automatic Control- Multidisciplinary design and optimization - Fluid Mechanics and Dynamics- Thermal-Fluids Machinery- Experimental and Computational Mechanics - Measurement and Instrumentation- HVAC- Manufacturing Systems- Materials Processing- Noise and Vibration- Composite and Polymer Materials- Biomechanical Engineering- Fatigue and Fracture Mechanics- Machine Components design- Gas Turbine- Power Plant Engineering- Artificial Intelligent/Neural Network- Robotic Systems- Solar Energy- Powder Metallurgy and Metal Ceramics- Discrete Systems- Non-linear Analysis- Structural Analysis- Tribology- Engineering Materials- Mechanical Systems and Technology- Pneumatic and Hydraulic Systems - Failure Analysis- Any other related topics.
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