评估变应性鼻炎和变应性鼻结膜炎患者在治疗前后的血清细胞因子和免疫球蛋白水平

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Віктор Богданов, Сергій Пухлік, Марія Макарова, Світлана Полякова, Кирило Богданов
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引用次数: 0

摘要

背景:近几十年来,变应性鼻炎(AR)的患病率在包括乌克兰在内的世界范围内呈上升趋势。变应性鼻结膜炎(ARC)是临床上最常见的变应性鼻结膜炎之一。促炎细胞因子和抗炎细胞因子之间的失衡是变应性炎症的关键因素。目的:比较不同治疗方案治疗的AR和ARC患者的细胞因子和免疫球蛋白水平。材料和方法:40例AR和ARC患者(年龄20 ~ 46岁)纳入研究。病程从6个月到2年不等。患者分为两个亚组,每组20例。亚组患者给予基础治疗(氯雷他定片10mg / d,糠酸莫米松鼻喷雾剂200 μg / d, 1次/ d),亚组患者给予基础治疗加多孔大菌(Astmagan) 1粒/ d, 2次/ d。疗程90 d。对照组由25名健康个体组成。在基线和疗程结束时进行了全面的临床免疫学检查。采用酶联免疫吸附测定试剂盒检测血清免疫球蛋白A (IgA)、IgM、IgG和IgE以及细胞因子(γ干扰素(IFN-γ)和il - 4)水平。结果:基线时,血清IgA、IgM和IgE水平几乎是基线时的两倍(χ = 0.0008;0.0005;和0.0001);IgG升高1.2倍(p < 0.001);促炎细胞因子IL4升高3.5倍(χ = 0.0001);和抗炎细胞因子IFN-γ,在AR和ARC患者中比对照组低2.4倍(r = 0.0001),这些差异是显著的。与单纯基础治疗相比,Astmagan作为AR和ARC基础治疗的辅助治疗时,血清IgA、IgM、IgE、IgG和IL4水平分别下降8%、17%、16.2%、7.3%和6.0%,血清IFN-γ水平增加16.6%,这些差异是显著的,并改善了免疫应答。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing serum cytokine and immunoglobulin levels in patients with allergic rhinitis and allergic rhinoconjunctivitis before and after treatment supplemented with macromycetes
Background: In recent decades, the prevalence of allergic rhinitis (AR) has been increasing all over the world including Ukraine. Allergic rhinoconjunctivitis (ARC) is one of the most common clinical forms of AR. An imbalance between pro-inflammatory and anti-inflammatory cytokines is known to have a key role in allergic inflammation. Purpose: To compare cytokine and immunoglobulin levels among patients with AR and ARC treated with different therapeutic options. Material and Methods: Forty patients with AR and ARC (age range, 20 to 46 years) were included in the study. Disease duration ranged from 6 months to 2 years. Patients were divided into two subgroups of 20 patients each. Patients of subgroup 1 received the basic therapy (a 10-mg loratadin tablet daily and mometasone furoate nasal spray at a dosage of 200 μg once daily), whereas patients of subgroup 2, the basic therapy plus polypore macromycetes (Astmagan), one capsule twice daily. Treatment course duration was 90 days. The control group was composed of 25 healthy individuals. A comprehensive clinical immunological examination was conducted at baseline and on the completion of the treatment course. Enzyme-linked immunosorbent assay kits were used to determine serum levels of immunoglobulins A (IgA), IgM, IgG, and IgE, and cytokines (gamma interferon (IFN-γ) and IL4). Results: At baseline, serum levels of IgA, IgM and IgE were almost twice as high (р = 0.0008; 0.0005; and 0.0001, respectively); IgG, 1.2 times higher (р = 0.001); pro-inflammatory cytokine IL4, 3.5 times higher (р = 0.0001); and anti-inflammatory cytokine IFN-γ, 2.4 times lower (р = 0.0001) in patients with AR and ARC compared to controls, and these differences were significant. Astmagan, when used as an adjunct to the basic treatment of AR and ARC, contributed to 8%, 17%, 16.2%, 7.3% and 6.0% greater decreases in the serum levels of IgA, IgM, IgE, IgG and IL4, respectively, and a 16.6% greater increase in the serum level of IFN-γ compared to the basic treatment only, and these differences were significant, with an improvement in immune response to therapy.
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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