腋臭洗液对腋臭患者ApoD和ABCC11 mRNA水平的影响

IF 0.6 4区医学 Q4 PHARMACOLOGY & PHARMACY

Tropical Journal of Pharmaceutical Research Pub Date : 2023-10-08 DOI:10.4314/tjpr.v22i9.16

Bin Chen, JiFeng Xie, KeKe Ding, ChunRong Gong

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引用次数: 0

摘要

目的:探讨腋臭洗剂在缓解腋臭(AO)中的潜在作用。方法:40例患者随机分为4组(n = 10)。在三个月的时间里，患者通过局部应用石斛、苦参、地皮或浸湿洗液治疗40分钟。用TRIzol提取皮肤总RNA，用DNase I处理血小板总RNA，然后用NanoDrop和Agilent 2100生物分析仪定量。结果:石斛、苦参、苦参能显著抑制AO患者ApoD和ABCC11 mRNA的表达(p <0.05)。此外，对AO患者ApoD和ABCC11 mRNA表达下调效果最好的是浸湿洗液。结论:这些自然疗法的抑制作用可能有利于非手术治疗AO的发展，值得进一步研究。

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Osmidrosis lotion affect ApoD and ABCC11 mRNA levels in axillary osmidrosis patients

Purpose: To investigate the potential role of osmidrosis lotion in alleviating axillary osmidrosis (AO).Methods: Forty patients were randomly divided into four groups (n = 10). Patients were treated via topical application of Lithargyrum, Sophora flavescens Alt., or Cortex dictamni, or osmidrosis lotion, for 40 min over a three-month period. Total skin RNA was extracted from samples using TRIzol while total platelet RNA was treated with DNase I, followed by quantification using NanoDrop and Agilent 2100 Bioanalyzer.Results: Lithargyrum, Sophora flavescens Alt. and Cortex dictamni significantly inhibited the mRNA expressions of ApoD and ABCC11 in AO patients (p < 0.05). Furthermore, osmidrosis lotion produced the best down-regulating effect on mRNA expressions of ApoD and ABCC11 in AO patients.Conclusion: The suppressive effect of these natural remedies may be beneficial in the development of non-surgical therapy for AO and therefore would be worth further investigation.

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来源期刊

Tropical Journal of Pharmaceutical Research 医学-药学

CiteScore

1.00

自引率

33.30%

发文量

490

审稿时长

4-8 weeks

期刊介绍： We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.