Evaluation of the antibacterial activity of nano berberine adsorbed bacterial cellulose material

Berberine can be considered a natural antibiotic plant with strong antibacterial and antifungal activities. The pr oblem of bioavailability and poor solubility can be overcome by formulating berberine at nanoparticles, which opens up a vast range of applications. In this study, berberine nanoparticles (BerNPs) were adsorbed on bacterial cellulose forming a composite with the potential for antibacterial material. The pr operties of BerNPs and before and after BerNPs adsorption were analysed by FE-SEM, XRD, and FT-IR methods. The antibacterial activity of BerNPs and its composite was examined invitro by the co-culture method with Escherichiacoli and Streptococcus pyogenes. The results indicated that BerNPs exhibited gr eat antibacterial pr operties against E. coliand S. pyogenes. The optimum capacity of loading BerNPs (50-60 nm) above the biological cellulose was after 2 hours of soaking. The against E. coli and S. pyogenes was over 80%.