慢性鼻窦炎代谢组学研究:临床前景综述

V. V. Dvoryanchikov, O. V. Kokorina, R. R. Achba, A. A. Samoilov, V. V. Turieva
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引用次数: 0

摘要

慢性鼻窦炎(CRS)是最常见的耳鼻喉科疾病之一,严重影响患者的生活质量。CRS的发病机制尚未得到充分的研究,预测治疗的有效性和可能的缓解期是有问题的。为了解决现代医学中的这些问题,开展了代谢组学研究,研究人体生物材料中的各种低分子代谢物和细胞成分:细胞、组织、液体、呼出的空气、唾液、支气管灌洗液等。代谢组学研究可以识别可能的疾病标记物并对其进行量化。结果,一组单独的分子参数被编译,形成患者的代谢谱。代谢组学研究在广泛的复杂人类疾病的临床预测中定义了一个新的水平,包括心血管疾病、肿瘤疾病、哮喘、糖尿病等。今天,典型的是使用结合了各种分子组学技术(基因组学、蛋白质组学、转录组学、脂质组学等)的多组学方法。基于已确定的定量测量的生物分子,可以将遗传变异与复杂的表型特征进行比较。关于CRS代谢组学研究的出版物并不广泛;然而,他们报告了各种形式的鼻窦炎的识别差异。CRS中的代谢组学研究可以确定各种形式的慢性鼻窦炎的诊断意义重大的分子标记,以及创建患者的个人组学资料,并提供控制治疗有效性的机会。结合患者生活方式和健康状况的完整数据,患者的个人欧姆概况可能是个性化医疗的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolomics studies in chronic rhinosinusitis: review of clinical prospects
Chronic rhinosinusitis (CRS) is one of the most common otorhinolaryngological diseases, which significantly reduces the quality of life of patients. The etiopathogenesis of CRS has not been fully studied to date, it is problematic to predict the effectiveness of the therapy and the possible period of remission. To solve such issues in modern medicine, metabolomic studies are carried out that study various low-molecular metabolites, cell components in biological material taken from a person: in a cell, tissue, fluid, exhaled air, saliva, bronchial lavage, etc. Metabolomic studies allow identifying possible disease markers and also quantifying them. As a result, a set of individual molecular parameters is compiled that form the patient’s metabolic profile. Metabolomic studies define a new level of clinical prediction in a wide range of complex human diseases, including cardiovascular, oncological diseases, asthma, diabetes, etc. Today, it is typical to use a multiomics approach that combines various molecular omics technologies (genomics, proteomics, transcriptomics, lipidomics, etc.). Based on the identified quantitatively measured biomolecules, it becomes possible to compare genetic variability with complex phenotypic features. Publications on metabolomic studies in CRS are not extensive; however, they report the identified differences in various forms of rhinosinusitis. Metabolomic studies in CRS allow determining the diagnostically significant molecular markers of various forms of chronic sinusitis as well as creating a personal omics profile of the patient and providing an opportunity to control the effectiveness of the therapy. Together with complete data on the patient’s lifestyle and health status, the patient’s personal ohmic profile may be the basis of personalized medicine.
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