Alirio Bastidas-Goyes, Eduardo Tuta-Quintero, Faure Yezid Rodríguez, Diego Holguín Riaño, Aldair Chaar Hernández, Lorena García Agudelo, Nicolas Peña Ramos, Carolina Gómez-Ruiz, Juan Giraldo-Vásquez, Doris Pumarejo-Villazón, María Henríquez-Rodríguez, Daniela Álvarez-Araujo, Paola Martínez-Artunduaga, Paola López Morales, Yesid Mantilla-Flórez, Luis F. Reyes
{"title":"与COVID-19长期死亡率相关的主要临床变量","authors":"Alirio Bastidas-Goyes, Eduardo Tuta-Quintero, Faure Yezid Rodríguez, Diego Holguín Riaño, Aldair Chaar Hernández, Lorena García Agudelo, Nicolas Peña Ramos, Carolina Gómez-Ruiz, Juan Giraldo-Vásquez, Doris Pumarejo-Villazón, María Henríquez-Rodríguez, Daniela Álvarez-Araujo, Paola Martínez-Artunduaga, Paola López Morales, Yesid Mantilla-Flórez, Luis F. Reyes","doi":"10.22354/24223794.1140","DOIUrl":null,"url":null,"abstract":"Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.","PeriodicalId":38132,"journal":{"name":"Infectio","volume":"6 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Main clinical variables related to long-term mortality in COVID-19\",\"authors\":\"Alirio Bastidas-Goyes, Eduardo Tuta-Quintero, Faure Yezid Rodríguez, Diego Holguín Riaño, Aldair Chaar Hernández, Lorena García Agudelo, Nicolas Peña Ramos, Carolina Gómez-Ruiz, Juan Giraldo-Vásquez, Doris Pumarejo-Villazón, María Henríquez-Rodríguez, Daniela Álvarez-Araujo, Paola Martínez-Artunduaga, Paola López Morales, Yesid Mantilla-Flórez, Luis F. Reyes\",\"doi\":\"10.22354/24223794.1140\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.\",\"PeriodicalId\":38132,\"journal\":{\"name\":\"Infectio\",\"volume\":\"6 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectio\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22354/24223794.1140\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectio","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22354/24223794.1140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Main clinical variables related to long-term mortality in COVID-19
Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.