口服抗凝治疗中剂量的计算机控制。

G Mariani, C Manotti, A G Dettori
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引用次数: 0

摘要

报道了一项关于人工心脏瓣膜(PHV)患者长期口服抗凝剂(OA)治疗质量的合作研究结果。这项研究是通过计算机辅助系统对695名患有PHV的患者进行的(1988年共进行了8,340次检查),以监测实验室和治疗随访。文中详细介绍了软件的规格。两个参与研究的中心(罗马和帕尔马)的平均INR略有不同(3.25 vs 3.19),口服抗凝剂的周平均剂量(18.2 vs 20.7 mg)也略有不同,口服抗凝剂均为阿塞诺古玛罗。通过每月对每位患者随机选择一次检查来评估,两个中心70%以上的检查都在范围内。考虑到整个数据,大约80%的患者在治疗范围内检查的次数大于50%,超过30%的患者在治疗范围内检查的次数大于75%。本研究表明,监测口服抗凝治疗的计算机程序的可用性允许进行多中心研究,并获得可以提高OA患者治疗质量的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A computerized regulation of dosage in oral anticoagulant therapy.

The results of a cooperative study on the quality of treatment of patients with prosthetic heart valves (PHV) on long-term oral anticoagulants (OA) are reported. The study was carried out on 695 patients bearing PHV (with an overall 8,340 checks carried out in 1988) through a computer-assisted system for monitoring the laboratory and treatment follow-up. The specifications of the software are described in detail in the text. The mean INR slightly differed in the two participating centers (Rome and Parma) (3.25 vs 3.19) as did the weekly mean dosage (18.2 vs 20.7 mg) of oral anticoagulant, which was always Acenocoumarol. More than 70% of the checks were within the range in both centers as evaluated by a check randomly chosen once a month for each single patient. Considering the whole bunch of data, about 80% of the patients had greater than 50% of their checks within the therapeutic range and more than 30% had greater than 75% of the checks within the range. This study demonstrates that the availability of a computerized program for monitoring oral anticoagulant therapy allows to perform multicenter studies and to obtain data which can improve the quality of treatment of patients on OA.

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