女性易患抑郁症的神经基础

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Minsoo Kim, Woonhee Kim, ChiHye Chung
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引用次数: 0

摘要

抑郁症在女性中更为普遍和严重;然而,我们对导致女性易患抑郁症的潜在因素的了解仍然有限。此外,在试图了解抑郁症机制的研究中,女性的代表性明显不足。人们设计了各种各样的抑郁症动物模型,但直到最近才将雌性纳入研究。在这篇全面的综述中,我们旨在描述抑郁症患者在患病率、病理生理和对药物治疗反应方面的性别差异。随后,我们重点研究了两性抑郁症的动物模型,以确定准确反映女性抑郁症易感性的模型。我们还介绍了抑郁症性别差异的神经基础的解释。值得注意的是,内侧前额叶皮层和伏隔核在先前的研究中表现出性别差异。此外,涉及多巴胺能中枢(腹侧被盖区)和血清素能中枢(中隔背核)的其他脑回路,以及它们各自的投射,已经显示出与抑郁有关的性别差异。总之,我们的综述涵盖了抑郁症性别差异的关键方面,特别关注人类女性的脆弱性及其在动物模型中的表现,包括潜在的潜在机制。采用合适的动物模型,有效地代表女性的脆弱性,将有助于我们理解抑郁症的性别依赖病理生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The neural basis underlying female vulnerability to depressive disorders
Depressive disorders are more prevalent and severe in women; however, our knowledge of the underlying factors contributing to female vulnerability to depression remains limited. Additionally, females are notably underrepresented in studies seeking to understand the mechanisms of depression. Various animal models of depression have been devised, but only recently have females been included in research. In this comprehensive review, we aim to describe the sex differences in the prevalence, pathophysiology, and responses to drug treatment in patients with depression. Subsequently, we highlight animal models of depression in which both sexes have been studied, in the pursuit of identifying models that accurately reflect female vulnerability to depression. We also introduce explanations for the neural basis of sex differences in depression. Notably, the medial prefrontal cortex and the nucleus accumbens have exhibited sex differences in previous studies. Furthermore, other brain circuits involving the dopaminergic center (ventral tegmental area) and the serotonergic center (dorsal raphe nucleus), along with their respective projections, have shown sex differences in relation to depression. In conclusion, our review covers the critical aspects of sex differences in depression, with a specific focus on female vulnerability in humans and its representation in animal models, including the potential underlying mechanisms. Employing suitable animal models that effectively represent female vulnerability would benefit our understanding of the sex-dependent pathophysiology of depression.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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