Loratadine-loaded Niosomal Transdermal Patch for Treating Allergic Issues: A Design Expert’s Associated Fabrication and Evaluation

Introduction: Loratadine (LRD) is a second-generation H1 histamineantagonist and is helpful in the treatment of allergies.Methods: The Box Behnken design (BBD) was used in this study tocreate nine LRD niosomes, which were then cast in solvent and put ontransdermal patches. The niosomes’ dimensions, shape, zeta potential,and degree of entrapment efficiency were then assessed. On the LRDentrapment, the niosomes’ cholesterol, Span-40, Span-60, and Span-80concentrations were measured. The patch system was filled with theoptimised niosomal formulations. Then, each patch was described using itsphysicochemical properties and results from in vitro permeation studies.Results: Patches containing niosomal vesicles, in contrast to controlpatches, demonstrated improved drug release. It was shown thatniosomal patches exhibited greater penetration than control patches.Niosomes’ surfactant serves as a permeation enhancer and enhancesLRD permeation from niosomes.Conclusion: The study concluded that the niosome-based transdermalpatches might effectively distribute LRD medications trans-dermallywhile minimising GIT adverse effects. How to cite this article:Sailaja C, Bhupalam PK. Loratadine-loadedNiosomal Transdermal Patch for Treating AllergicIssues: A Design Expert’s Associated Fabricationand Evaluation. Chettinad Health City Med J.2023;12(3):69-78. DOI: https://doi.org/10.24321/2278.2044.202354