D. Grbic, R. Loomba, V. Cejvanovic, J. Iyer, M. Kjaer, N. Krarup, A. Sejling, J. Pericas
{"title":"西马鲁肽对非酒精性脂肪性肝炎肝硬化患者肝脏组织学影响的机器学习模型评估与病理评估比较","authors":"D. Grbic, R. Loomba, V. Cejvanovic, J. Iyer, M. Kjaer, N. Krarup, A. Sejling, J. Pericas","doi":"10.1016/j.jcjd.2023.10.286","DOIUrl":null,"url":null,"abstract":"In trials of non-alcoholic steatohepatitis (NASH), liver biopsies are evaluated by pathologists; however, machine learning (ML) has shown promise in assessing biopsies. PathAI has developed ML models to provide such assessments. This post-hoc analysis included data from a randomized, double-blind, placebo-controlled phase 2 trial (NCT03987451) of patients with compensated NASH cirrhosis to study the effects of semaglutide on individual histological components of NASH assessed by the ML models.","PeriodicalId":93918,"journal":{"name":"Canadian journal of diabetes","volume":"335 6","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"COMPARISON OF THE EFFECTS OF SEMAGLUTIDE ON LIVER HISTOLOGY IN PATIENTS WITH NON-ALCOHOLICS STEATOHEPATITIS CIRRHOSIS BETWEEN MACHINE LEARNING MODEL ASSESSMENT AND PATHOLOGIST EVALUATION\",\"authors\":\"D. Grbic, R. Loomba, V. Cejvanovic, J. Iyer, M. Kjaer, N. Krarup, A. Sejling, J. Pericas\",\"doi\":\"10.1016/j.jcjd.2023.10.286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In trials of non-alcoholic steatohepatitis (NASH), liver biopsies are evaluated by pathologists; however, machine learning (ML) has shown promise in assessing biopsies. PathAI has developed ML models to provide such assessments. This post-hoc analysis included data from a randomized, double-blind, placebo-controlled phase 2 trial (NCT03987451) of patients with compensated NASH cirrhosis to study the effects of semaglutide on individual histological components of NASH assessed by the ML models.\",\"PeriodicalId\":93918,\"journal\":{\"name\":\"Canadian journal of diabetes\",\"volume\":\"335 6\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian journal of diabetes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jcjd.2023.10.286\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of diabetes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jcjd.2023.10.286","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
COMPARISON OF THE EFFECTS OF SEMAGLUTIDE ON LIVER HISTOLOGY IN PATIENTS WITH NON-ALCOHOLICS STEATOHEPATITIS CIRRHOSIS BETWEEN MACHINE LEARNING MODEL ASSESSMENT AND PATHOLOGIST EVALUATION
In trials of non-alcoholic steatohepatitis (NASH), liver biopsies are evaluated by pathologists; however, machine learning (ML) has shown promise in assessing biopsies. PathAI has developed ML models to provide such assessments. This post-hoc analysis included data from a randomized, double-blind, placebo-controlled phase 2 trial (NCT03987451) of patients with compensated NASH cirrhosis to study the effects of semaglutide on individual histological components of NASH assessed by the ML models.
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