两种新鲜黄连木含油提取物的植物化学分析及生物活性研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-19 DOI:10.4314/bcse.v37i6.15

Omayma Abidi, Zaineb Abdelkafi-Koubaa, Nadia Fares-Zagrouba, Salem Elkahoui, Lamjed Toumi, Lamjed Marzouki, Ouajdi Souilem

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引用次数: 0

摘要

摘要本研究旨在研究扁豆皮(Pistacia lentiscus L.， P. lentiscus)提取物的抗癌、抑菌和抗氧化活性，以及其植物化学特征。GC-MS粗化学谱提供了固定油(FO)和精油(EO)提取物的新化学类型。次生代谢物筛选出高含量的多酚和浓缩单宁，而鱼油中黄酮类化合物含量最高。两种提取物对两种人乳腺癌细胞(EO-IC50 = 5.2 mg/mL MDA-MB-231细胞)均有较强的抗增殖活性。抑菌活性表明，只有EO对6株多药耐药菌(抑制区20 ~ 8 mm)和2株真菌(抑制区3 ~ 4 mm)有抑菌活性。体外抗氧化自由基清除能力最高的是EO (125.5 μg/mL)。在体内，对雌性小鼠C57BL/6 (t57bl /6)所致的肝、肾氧化损伤有一定的纠正作用。这些发现证实了EO抑制细胞增殖，诱导细菌死亡，并具有潜在的抗氧化活性。关键词:植物疗法;黄连木;抗氧化;公牛。化学。Soc。中国生物医学工程学报，2016,37(6)，1487-1501。DOI: https://dx.doi.org/10.4314/bcse.v37i6.15

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Phytochemical analysis and biological activities of two oil-bearing extracts from fresh Pistacia lentiscus

ABSTRACT. This study aims to investigate the anti-cancer, antimicrobial and antioxidant activities of Pistacia lentiscus L. (P. lentiscus) extracts, as well as their phyto-chemical profile. The GC-MS crude chemical profile provided new chemotypes of fixed oil (FO) and essential oil (EO) extracts. Secondary metabolites screened high levels of polyphenols and condensed tannins in EO, while FO had the highest flavonoids content. A potent anti-proliferative activity of both extracts was shown on two human breast cancer cells (EO-IC50 = 5.2 mg/mL MDA-MB-231 cells). The antimicrobial activity showed that only EO was active against six multidrug resistant bacteria (inhibition zone 20-8 mm) and two fungi strains (inhibition zone 3-4 mm). Also, the highest in vitro antioxidant free-radical scavenging ability was in the case of EO (125.5 μg/mL). In vivo P. lentiscus EO provided corrective effect vs the tamoxifen (Txf) induced oxidative damage in liver and kidney in C57BL/6 in female mouse. These findings confirm that EO inhibits cell proliferation, induces bacterial death and has a potential antioxidant activity. KEY WORDS: Phytotherapy, Pistacia lentiscus, Antioxidant, Antimicrobial activity, Breast cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1487-1501. DOI: https://dx.doi.org/10.4314/bcse.v37i6.15

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.