参与艾伯塔省明天项目的男性在诊断时与前列腺癌阶段有关的健康和社会心理因素

IF 2.3 Q3 ONCOLOGY
Michelle L. Aktary, Brittany Shewchuk, Qinggang Wang, Eric Hyndman, Lorraine Shack, Paula J. Robson, Karen A. Kopciuk
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引用次数: 0

摘要

前列腺癌(PCa)的诊断分期是预测预后的重要指标。在加拿大,超过四分之一的男性被诊断为晚期前列腺癌。研究已经确定了与前列腺癌诊断阶段相关的几个因素;然而,来自加拿大的证据有限。本研究旨在探讨社会人口统计学特征、健康史、健康习惯和心理社会因素与加拿大阿尔伯塔省明日计划(ATP)男性前列腺癌诊断阶段之间的关系。该研究包括年龄在35-69岁之间的男性,他们在2018年1月之前患有前列腺癌。诊断时与前列腺癌分期相关的因素采用部分比例odds (PPO)有序回归模型进行检验。在研究期间,共有410名男性被诊断为前列腺癌。终生前列腺特异性抗原检测次数较高与早期PCa相关(OR 0.91, p = 0.02, 95% CI 0.83-0.99),而较高的腹围(OR 1.02, p = 0.05, 95% CI 1.00-1.03),较低的社会支持(OR 2.34, p <0.01, 95% CI 1.31-4.17),有孩子(OR 2.67, p <0.01, 95% CI 1.38-5.16)与晚期疾病相关。本研究确定了先前文献中发现的因素以及与前列腺癌诊断阶段相关的新因素,这可以帮助告知癌症预防计划的目标,以改善前列腺癌预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Health-Related and Psychosocial Factors Associated with Prostate Cancer Stage at Diagnosis among Males Participating in Alberta’s Tomorrow Project
Prostate cancer (PCa) stage at diagnosis is an important predictor of cancer prognosis. In Canada, over one-quarter of males are diagnosed with advanced-stage PCa. Studies have identified several factors associated with PCa stage at diagnosis; however, evidence from Canada is limited. This study aimed to examine associations between sociodemographic characteristics, health history, health practices, and psychosocial factors and PCa stage at diagnosis among males participating in Alberta’s Tomorrow Project (ATP), a prospective cohort in Alberta, Canada. The study included males aged 35–69 years who developed PCa until January 2018. Factors associated with PCa stage at diagnosis were examined using partial proportional odds (PPO) ordinal regression models. A total of 410 males were diagnosed with PCa over the study period. A higher number of lifetime prostate-specific antigen tests were associated with earlier-stage PCa (OR 0.91, p = 0.02, 95% CI 0.83–0.99), while higher abdominal circumference (OR 1.02, p = 0.05, 95% CI 1.00–1.03), lower social support (OR 2.34, p < 0.01, 95% CI 1.31–4.17), and having children (OR 2.67, p < 0.01, 95% CI 1.38–5.16) were associated with later-stage disease. This study identified factors previously found in the literature as well as novel factors associated with PCa stage at diagnosis, which can help inform targets for cancer prevention programs to improve PCa prognosis.
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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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