组织工程和肩关节、髋关节、膝关节和踝关节再生中的生物力学力

Merlin Rajesh Lal LP, Devendra K Agrawal
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引用次数: 0

摘要

肌腱、韧带和关节软骨的撕裂不能自行愈合,需要新的治疗方式来解决关节功能完全恢复的需要。伴随着退行性疾病,这些组织的愈合不能自然发生,因此需要手术干预,但有相关的发病率。组织工程策略现在集中于有效结合生物力学刺激,通过应用与感兴趣的组织相关的生物力学力来再生和工程功能组织。生物反应器正在不断发展以实现这一目标。尽管生物反应器已经被开发出来,但生物材料、基础科学和细胞工程领域的进步要求进一步改进以使其有效利用。本文综述了生物力学力在肩关节袖、髋关节球窝关节、膝关节软骨、踝关节等关节组织工程和再生中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomechanical Forces in the Tissue Engineering and Regeneration of Shoulder, Hip, Knee, and Ankle Joints
Tear on the tendon, ligament and articular cartilage of the joints do not heal by itself and new modalities of treatment are required to address the need for full restoration of joint functions. Accompanied by degenerative diseases, the healing of these tissues does not occur naturally and hence requires surgical interventions, but with associated morbidity. Tissue engineering strategies are now focusing on the effective incorporation of biomechanical stimulation by the application of biomechanical forces relevant to the tissue of interest to regenerate and engineer functional tissues. Bioreactors are being continuously developed to accomplish this goal. Although bioreactors have been developed, the advancement in the field of biomaterial, basic science, and cell engineering warrant further refinement for their effective use. In this article we reviewed the application of biomechanical forces in the tissue engineering and regeneration of the joints such as rotator cuff of shoulder, ball and socket joint of the hip, articular cartilage of knee, and the ankle joints.
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