男性不育的精子DNA断裂:从实验到临床

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Arab Journal of Urology Pub Date : 2023-11-12 DOI:10.1080/20905998.2023.2278200

Ala’a Farkouh, Ramadan Saleh, Rupin Shah, Ashok Agarwal

{"title":"男性不育的精子DNA断裂:从实验到临床","authors":"Ala’a Farkouh, Ramadan Saleh, Rupin Shah, Ashok Agarwal","doi":"10.1080/20905998.2023.2278200","DOIUrl":null,"url":null,"abstract":"Objectives Sperm DNA fragmentation (SDF) is a molecular marker of sperm chromatin health. Elevated SDF is associated with male infertility, recurrent pregnancy loss, and failure of assisted reproductive technologies (ART). In 2021, the sixth edition of the World Health Organization (WHO) Manual for the Laboratory Examination and Processing of Human Semen has listed SDF as an extended test of semen that can be ordered under certain circumstances. However, the manual neither explained the indications for testing nor provided clear guidance on diagnostic thresholds.","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"26 10","pages":"0"},"PeriodicalIF":1.3000,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sperm DNA fragmentation in male infertility: From bench to bedside\",\"authors\":\"Ala’a Farkouh, Ramadan Saleh, Rupin Shah, Ashok Agarwal\",\"doi\":\"10.1080/20905998.2023.2278200\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives Sperm DNA fragmentation (SDF) is a molecular marker of sperm chromatin health. Elevated SDF is associated with male infertility, recurrent pregnancy loss, and failure of assisted reproductive technologies (ART). In 2021, the sixth edition of the World Health Organization (WHO) Manual for the Laboratory Examination and Processing of Human Semen has listed SDF as an extended test of semen that can be ordered under certain circumstances. However, the manual neither explained the indications for testing nor provided clear guidance on diagnostic thresholds.\",\"PeriodicalId\":8113,\"journal\":{\"name\":\"Arab Journal of Urology\",\"volume\":\"26 10\",\"pages\":\"0\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arab Journal of Urology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/20905998.2023.2278200\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20905998.2023.2278200","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的精子DNA断裂(SDF)是精子染色质健康状况的分子标志物。SDF升高与男性不育、复发性流产和辅助生殖技术(ART)失败有关。2021年，世界卫生组织(世卫组织)第六版《人类精液实验室检查和处理手册》将SDF列为在某些情况下可订购的精液扩展检测。然而，该手册既没有解释检测的适应症，也没有提供诊断阈值的明确指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Sperm DNA fragmentation in male infertility: From bench to bedside

Objectives Sperm DNA fragmentation (SDF) is a molecular marker of sperm chromatin health. Elevated SDF is associated with male infertility, recurrent pregnancy loss, and failure of assisted reproductive technologies (ART). In 2021, the sixth edition of the World Health Organization (WHO) Manual for the Laboratory Examination and Processing of Human Semen has listed SDF as an extended test of semen that can be ordered under certain circumstances. However, the manual neither explained the indications for testing nor provided clear guidance on diagnostic thresholds.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.