一些新的苯并三唑衍生物:合成、抑菌评价、抑菌效果、ADME研究和分子对接研究

IF 0.2 4区化学 Q4 CHEMISTRY, ORGANIC

Indian Journal of Heterocyclic Chemistry Pub Date : 2023-09-30 DOI:10.59467/ijhc.2023.33.385

Nigam Jyoti Maiti, Swastika Ganguly

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引用次数: 0

摘要

合成了一系列新的取代苯-2-(高氯- 1h -苯并[d][1,2,3]三唑-1-基)乙二酮衍生物3(A -j)，并对其抑菌活性和抗菌活性进行了评价。在所有被测化合物中，化合物3h表现出最高的抑菌活性，与标准药物相当。最后，在结核分枝杆菌(PDB ID 2×22)和葡萄糖胺-6-磷酸合酶(PDB ID 2VF5)的活性结合位点共结晶结构上对高活性化合物进行结合模式分析。

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Some New Benzotriazole Derivatives: Synthesis, Antimycobacterial Evaluation, Antimicrobial Efficacy, ADME Studies, and Molecular Docking Studies

A series of new substituted phenyl-2-(perchloro-1H-benzo[d][1,2,3]triazol-1-yl)ethan-1-one derivatives 3(a-j) was synthesized, and evaluated for antimycobacterial and antimicrobial activity. Among all the tested compounds, compound 3h exhibited the highest antimycobacterial and antibacterial activity, comparable to the standard drug. Finally, the binding mode analysis of the highly active compounds was performed in the active binding site, the co-crystallized structure of Mycobacterium tuberculosis (PDB ID 2×22) and glucosamine-6-phosphate synthase (PDB ID 2VF5).

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来源期刊

Indian Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

0.40

自引率

33.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Heterocyclic Chemistry is exclusively devoted to research in the area of heterocyclic chemistry. The journal publishes invited review articles and original research papers pertaining to structure and synthesis, mechanism of reactions, spectral studies, biologically active compounds, bio-chemical studies, physicochemical work, phytochemistry etc.