乳酸/白蛋白比值升高与脓毒症患者预后不良相关:一项系统综述和荟萃分析

IF 2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xian Zhao, Qin Peng, Weiwei Li, Dongmei Hu, Yue Guan, Jingwen Wang
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引用次数: 0

摘要

背景:本研究旨在探讨乳酸/白蛋白比值与脓毒症患者预后的关系。 方法:计算机检索Pubmed、EMbase、Ovid、Medline和谷歌Scholar,整理相关研究。采用标准化平均差异(SMD)/优势比(OR)和95%置信区间(CI)对结果进行比较。前瞻性和回顾性队列研究均纳入本研究。 结果:共纳入9项研究,涉及3039名受试者。合并分析显示,幸存者的乳酸/白蛋白比明显低于非幸存者(SMD=-2.02, 95% CI: -2.76至-1.28,I2=97.4%)。此外,我们的研究结果还表明,乳酸/白蛋白比值升高是脓毒症患者死亡率(OR=2.16, 95% CI: 1.58 ~ 2.95, I2=76.2%)和多器官功能障碍综合征(MODS) (OR=3.41, 95% CI: 1.78 ~ 6.50, I2=0.0%)的独立危险因素。此外,根据曲线下面积(AUC)结果,乳酸/白蛋白比值对预测脓毒症患者的死亡率(AUC=0.75, 95% CI: 0.68 ~ 0.84, I2=92.9%)和MODS (AUC=0.78, 95% CI: 0.68 ~ 0.91, I2=65.1%)也具有良好的判别能力。Begg’s和Egger’s检验表明纳入的研究没有发表偏倚。 结论:我们的研究结果强调乳酸/白蛋白比值是脓毒症患者MODS和死亡率的重要预后因素,具有较好的识别MODS和死亡率的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elevated lactate/albumin ratio is associated with poor prognosis in sepsis patients: a systematic review and meta-analysis
Background: The aim of this study was to explore the association between lactate/albumin ratio and the prognosis of sepsis patients. Methods: A computerized search was performed in Pubmed, EMbase, Ovid, Medline, and Google Scholar to collate relevant studies. The results were compared using standardized mean differences (SMD)/odds ratio (OR) and 95% confidence intervals (CI). Prospective and retrospective cohort studies were both included in this study. Results: A total of nine studies involving 3039 participants were included. Pooled analysis revealed that survivors had substantially lower lactate/albumin ratio than non-survivors (SMD=-2.02, 95% CI: -2.76 to -1.28, I2=97.4%). Further, our results also indicated that elevated lactate/albumin ratio is an independent risk factor for mortality (OR=2.16, 95% CI: 1.58 to 2.95, I2=76.2%) and multiple organ dysfunction syndrome (MODS) (OR=3.41, 95% CI: 1.78 to 6.50, I2=0.0%) in septic patients. Moreover, according to the area under curve (AUC) results, the lactate/albumin ratio also presented good discriminatory power to predict mortality (AUC=0.75, 95% CI: 0.68 to 0.84, I2=92.9%) and MODS (AUC=0.78, 95% CI: 0.68 to 0.91, I2=65.1%) in septic patients. Begg's and Egger's test suggested no publication bias in the included studies. Conclusions: Our results highlighted that the lactate/albumin ratio is an important prognostic factor for MODS and mortality in sepsis patients, having good capabilities in identifying MODS and mortality.
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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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