土耳其院内感染COVID-19的临床特征和结局:一项回顾性多中心研究

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Asian Pacific journal of tropical medicine Pub Date : 2023-08-01 DOI:10.4103/1995-7645.383912

Süleyman Yıldırım, Celalettin Yılmaz, Gülru Polat, Serap Argun Baris, İlknur Başyiğit, İlknur Kaya, Ceyda Anar, Mihriban Bozkurt, Hüsnü Baykal, Hulya Dirol, Gamzenur Ozbey, Emine Ozsari, Emel Cireli, Ali Kadri Çırak, Dursun Tatar, Mine Gayaf, Selen Karaoglanoglu, Yener Aydin, Atilla Eroglu, Yıldız Olçar, Berna Botan Yıldırım, Bengül Gürsoy, Deniz Demir Yılmaz, Elif Yelda Ozgun Niksarlioglu, Ramazan Eren, Ayşegül Tomruk Erdem, Müge Meltem Tor, Fusun Fakili, Mustafa Çolak, Merve Erçelik, Ali Tabaru, Özlem Ediboglu

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引用次数: 0

摘要

目的:了解土耳其全国疫苗接种期间医院获得性SARS-CoV-2感染的临床特征和结局。方法:回顾性调查2021年1月1日至2022年3月31日期间在土耳其全国大流行服务中心随访的COVID-19患者。医院源性COVID-19定义为入院时既未诊断为COVID-19，也未怀疑为COVID-19，且入院后≥5天确诊为COVID-19的患者。本研究的主要结局是住院死亡率;比较幸存者和非幸存者的人口统计学特征和疫苗接种状况。结果:在研究期间，18个中心共随访了15 573例COVID-19患者，其中543例(3.5%)为医院源性COVID-19。医院源性COVID-19患者大部分(80.4%)是从内科病房转移过来的。医院源性COVID-19患者因病情严重入住重症监护病房162例(29.8%)，住院期间死亡138例(25.4%)。高龄(≥65岁)和合并症(≥2种)与院内感染COVID-19的死亡率相关(OR分别为1.74,95% Cl 1.11-2.74和1.60,95% Cl 1.02-2.56)。接种疫苗与医院源性COVID-19患者的生存率相关(OR 0.25, 95% Cl 0.16-0.38)。结论:院内感染的COVID-19患者入住重症监护病房的人数增加，死亡率较高。接种疫苗可以降低住院死亡率。

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Clinical characteristics and outcomes of nosocomial COVID-19 in Turkey: A retrospective multicenter study

Objective: To identify the clinical characteristics and outcomes of hospital-acquired SARS-CoV-2 infection during the vaccination period nationwide in Turkey. Methods: COVID-19 patients followed in the pandemic services across Turkey between January 1, 2021, and March 31, 2022 were investigated retrospectively. Nosocomial COVID-19 was defined as a patient neither diagnosed with COVID-19 nor suspected COVID-19 at the hospital admission and was confirmed COVID-19 ≥5 days after hospital admission. The primary outcome of this study was in-hospital mortality; demographic features and vaccination status was compared between survivors and non-survivors. Results: During the study period, 15 573 COVID-19 patients were followed in 18 centers and 543 (3.5%) patients were nosocomial COVID-19. Most patients with nosocomial COVID-19 (80.4%) were transferred from medical wards. 162 (29.8%) of the patients with nosocomial COVID-19 admitted to the intensive care unit due to disease severity and 138 (25.4%) of the patients died during hospital stay. Advanced age (≥65 years) and number of comorbid diseases (≥2) was found to be associated with mortality in nosocomial COVID-19 ( OR 1.74, 95% Cl 1.11-2.74 and OR 1.60, 95% Cl 1.02-2.56, respectively). Vaccination was associated with survival in nosocomial COVID-19 ( OR 0.25, 95% Cl 0.16-0.38). Conclusions: Patients with nosocomial COVID-19 had increased admission to intensive care units and higher mortality rate. Vaccination can decrease the in-hospital mortality rate.

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来源期刊

Asian Pacific journal of tropical medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TROPICAL MEDICINE

CiteScore

4.00

自引率

9.70%

发文量

1936

审稿时长

3-8 weeks

期刊介绍： Asian Pacific Journal of Tropical Medicine (ISSN 1995-7645 CODEN: APJTB6), a publication of Editorial office of Hainan Medical University,is a peer-reviewed print + online Monthly journal. The journal''s full text is available online at http://www.apjtm.org/. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. APJTM aims to provide an academic communicating platform for international physicians, medical scientists, allied health scientists and public health workers, especially those of the Asia-Pacific region and worldwide on tropical medicine, infectious diseases and public health, and to meet the growing challenges of understanding, preventing and controlling the dramatic global emergence and re-emergence of infectious diseases in the Asia-Pacific. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on tropical medicine, infectious diseases and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. The APJTM will allow us to seek opportunities to work with others who share our aim, and to enhance our work through partnership, and to uphold the standards of our profession and contribute to its advancement.