利用唾液酸独特的化学结构合成神经节苷类化合物的研究进展

IF 0.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI:10.4052/tigg.2312.2e

Hide-Nori Tanaka

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引用次数: 0

摘要

神经节苷是脂筏的组成部分，参与许多生物事件，如信号转导。为了在分子水平上阐明脂筏的形成机制和功能，结构明确的神经节苷的合成是必要的。然而，先前实现唾液酸糖苷键形成立体控制的方法表明，它是底物依赖的。因此，神经节苷及其聚糖的化学合成仍然是碳水化合物化学中的一项具有挑战性的任务。本文综述了1,5-内酰胺合成神经节苷类化合物的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Development of a Synthetic Strategy for Gangliosides Using the Unique Chemical Structure of Sialic Acid

Gangliosides are the components of lipid rafts involved in several biological events such as signal transduction. The synthesis of structurally well-defined gangliosides is necessary in order to elucidate the formation mechanisms and functions of lipid rafts at the molecular level. However, previous methods to achieve stereocontrol in glycosidic bond formation of sialic acid have shown that it is substrate-dependent. Therefore, the chemical synthesis of gangliosides and their glycans remains a challenging task in carbohydrate chemistry. This review presents the development of a 1,5-lactam synthetic strategy for gangliosides.

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来源期刊

Trends in Glycoscience and Glycotechnology 生物-生化与分子生物学

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： TIGG is an international, bilingual journal covering glycoscience and glycotechnology and issued bimonthly since 1989. Since then editors are elected from academia and companies who agree to participate in a volunteer basis for the duration of four years. TIGG is an official journal of the Japanese Society of Carbohydrate Research. The journal covers the following categories. MINIREVIEWS describe recent progress in the fields of glycoscience and glycotechnology. Suggestions are always welcome in the form of a one-page synopsis (double spaced) addressed to the editor-in-chief. GLYCOTOPICS are short commentaries on the latest papers describing outstanding findings with background. GLYCODEBUTS introduce distinguished PhD theses or outstanding works of young scientists over the world in glycosciences and glycotechnologies. GLYCOFORUM is for our readers who wish to submit comments on scientific or social matters related to glycoscience and glycotechnology. LETTERS TO TIGG are for readers who wish to discuss contributions appearing in TIGG or matters related to FCCA.