5周摄入赤藓糖醇和木糖醇对肥胖患者血管功能、腹部脂肪和葡萄糖耐量的影响:一项试点试验

IF 3.3 Q2 NUTRITION & DIETETICS
Valentine Bordier, Fabienne Teysseire, Jürgen Drewe, Philipp Madörin, Oliver Bieri, Arno Schmidt-Trucksäss, Henner Hanssen, Christoph Beglinger, Anne Christin Meyer-Gerspach, Bettina K Wölnerhanssen
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Before and after the intervention, arterial stiffness (pulse wave velocity, arteriolar-to-venular diameter ratio), abdominal fat (liver volume, liver fat percentage, visceral and subcutaneous adipose tissue, blood lipids), glucose tolerance (glucose and insulin concentrations), uric acid, hepatic enzymes, creatinine, gastrointestinal tolerance and dietary patterns were assessed. Data were analysed by linear mixed effect model. Results The 5-week intake of erythritol and xylitol showed no statistically significant effect on vascular function. Neither the time nor the treatment effects were significantly different for pulse wave velocity (time effect: p=0.079, Cohen’s D (95% CI) −0.14 (−0.54–0.25); treatment effect: p=0.792, Cohen’s D (95% CI) control versus xylitol: −0.11 (–0.61–0.35), control versus erythritol: 0.05 (0.44–0.54), erythritol versus xylitol: 0.07 (–0.41–0.54)). 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引用次数: 0

摘要

先前对人类和大鼠的研究表明赤藓糖醇可能对血管功能有积极影响,木糖醇可以减少内脏脂肪量,两种物质都可以改善血糖控制。本研究的目的是调查5周摄入赤藓糖醇和木糖醇对肥胖人群血管功能、腹部脂肪和血脂、葡萄糖耐量、尿酸、肝酶、肌酐、胃肠耐量和饮食模式的影响。方法将42名受试者随机分为每天服用36 g赤藓糖醇、24 g木糖醇和不服用任何药物组,持续5周。在干预前后,评估动脉硬度(脉搏波速度、小动脉与静脉直径比)、腹部脂肪(肝脏体积、肝脏脂肪百分比、内脏和皮下脂肪组织、血脂)、葡萄糖耐量(葡萄糖和胰岛素浓度)、尿酸、肝酶、肌酐、胃肠耐量和饮食模式。数据采用线性混合效应模型进行分析。结果5周摄入赤藓糖醇和木糖醇对血管功能无显著影响。脉冲波速在时间和治疗效果上均无显著差异(时间效应:p=0.079, Cohen 's D (95% CI) - 0.14 (- 0.54-0.25);治疗效果:p=0.792, Cohen 's D (95% CI)对照与木糖醇:- 0.11(-0.61-0.35),对照与赤糖醇:0.05(0.44-0.54),赤糖醇与木糖醇:0.07(-0.41-0.54))。对腹部脂肪、葡萄糖耐量、尿酸、肝酶和肌酐的影响无统计学意义。除少数腹泻相关症状外,胃肠道耐受性良好。与干预前相比,所有组的参与者都减少了含糖饮料和糖果的摄入量。结论:5周摄入赤藓糖醇和木糖醇对肥胖患者的血管功能、腹部脂肪或葡萄糖耐量无统计学意义的影响。临床试验注册编号NCT02821923。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial
Introduction Previous studies in humans and rats suggest that erythritol might positively affect vascular function, xylitol decrease visceral fat mass and both substances improve glycaemic control. The objective of this study was to investigate the impact of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and blood lipids, glucose tolerance, uric acid, hepatic enzymes, creatinine, gastrointestinal tolerance and dietary patterns in humans with obesity. Methods Forty-two participants were randomised to consume either 36 g erythritol, 24 g xylitol, or no substance daily for 5 weeks. Before and after the intervention, arterial stiffness (pulse wave velocity, arteriolar-to-venular diameter ratio), abdominal fat (liver volume, liver fat percentage, visceral and subcutaneous adipose tissue, blood lipids), glucose tolerance (glucose and insulin concentrations), uric acid, hepatic enzymes, creatinine, gastrointestinal tolerance and dietary patterns were assessed. Data were analysed by linear mixed effect model. Results The 5-week intake of erythritol and xylitol showed no statistically significant effect on vascular function. Neither the time nor the treatment effects were significantly different for pulse wave velocity (time effect: p=0.079, Cohen’s D (95% CI) −0.14 (−0.54–0.25); treatment effect: p=0.792, Cohen’s D (95% CI) control versus xylitol: −0.11 (–0.61–0.35), control versus erythritol: 0.05 (0.44–0.54), erythritol versus xylitol: 0.07 (–0.41–0.54)). There was no statistically significant effect on abdominal fat, glucose tolerance, uric acid, hepatic enzymes and creatinine. Gastrointestinal tolerance was good except for a few diarrhoea-related symptoms. Participants of all groups reduced their consumption of sweetened beverages and sweets compared with preintervention. Conclusions The 5-week intake of erythritol and xylitol showed no statistically significant effects on vascular function, abdominal fat, or glucose tolerance in people with obesity. Clinical trial registration NCT02821923 .
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来源期刊
BMJ Nutrition, Prevention and Health
BMJ Nutrition, Prevention and Health Nursing-Nutrition and Dietetics
CiteScore
5.80
自引率
0.00%
发文量
34
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