非洲分子自闭症研究:新兴主题和普遍差异

IF 2.9 3区心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL

Review Journal of Autism and Developmental Disorders Pub Date : 2023-11-14 DOI:10.1007/s40489-023-00415-0

Emma Frickel, Caitlyn Mahony, Sophia Bam, Erin Buchanan, Mignon van der Watt, Colleen O’Ryan

{"title":"非洲分子自闭症研究:新兴主题和普遍差异","authors":"Emma Frickel, Caitlyn Mahony, Sophia Bam, Erin Buchanan, Mignon van der Watt, Colleen O’Ryan","doi":"10.1007/s40489-023-00415-0","DOIUrl":null,"url":null,"abstract":"Abstract African populations are consistently underrepresented in molecular research on autism spectrum disorders (ASD). Yet, Africa’s genetic diversity could reveal novel mechanisms associated with ASD etiology. We review the molecular ASD research from Africa between 2016–2022, highlighting region-specific limitations, opportunities, and areas of progress. We emphasize a need to advance null-hypothesis based molecular studies in Africa, particularly in critically understudied Sub-Saharan African (SSA) populations. Using South Africa as a case study, we show that this geographical disparity is not solely attributable to sociocultural barriers nor to an absence of molecular research infrastructure. We emphasize the importance of interdisciplinary collaboration within SSA and internationally to harness existing infrastructure for the expansion of molecular ASD research in Africa.","PeriodicalId":46647,"journal":{"name":"Review Journal of Autism and Developmental Disorders","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular Autism Research in Africa: Emerging Themes and Prevailing Disparities\",\"authors\":\"Emma Frickel, Caitlyn Mahony, Sophia Bam, Erin Buchanan, Mignon van der Watt, Colleen O’Ryan\",\"doi\":\"10.1007/s40489-023-00415-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract African populations are consistently underrepresented in molecular research on autism spectrum disorders (ASD). Yet, Africa’s genetic diversity could reveal novel mechanisms associated with ASD etiology. We review the molecular ASD research from Africa between 2016–2022, highlighting region-specific limitations, opportunities, and areas of progress. We emphasize a need to advance null-hypothesis based molecular studies in Africa, particularly in critically understudied Sub-Saharan African (SSA) populations. Using South Africa as a case study, we show that this geographical disparity is not solely attributable to sociocultural barriers nor to an absence of molecular research infrastructure. We emphasize the importance of interdisciplinary collaboration within SSA and internationally to harness existing infrastructure for the expansion of molecular ASD research in Africa.\",\"PeriodicalId\":46647,\"journal\":{\"name\":\"Review Journal of Autism and Developmental Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2023-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Review Journal of Autism and Developmental Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s40489-023-00415-0\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHOLOGY, DEVELOPMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Review Journal of Autism and Developmental Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40489-023-00415-0","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHOLOGY, DEVELOPMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

非洲人群在自闭症谱系障碍(ASD)的分子研究中一直代表性不足。然而，非洲的遗传多样性可能揭示与ASD病因相关的新机制。我们回顾了2016-2022年非洲的分子ASD研究，强调了区域特定的局限性、机遇和进展领域。我们强调有必要在非洲推进基于零假设的分子研究，特别是在研究严重不足的撒哈拉以南非洲(SSA)人群中。以南非为例，我们表明这种地理差异不仅仅是由于社会文化障碍，也不是由于缺乏分子研究基础设施。我们强调在非洲自闭症分子机制框架内和国际上开展跨学科合作的重要性，利用现有基础设施扩大非洲自闭症分子机制研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Molecular Autism Research in Africa: Emerging Themes and Prevailing Disparities

查看原文本刊更多论文

Molecular Autism Research in Africa: Emerging Themes and Prevailing Disparities

Abstract African populations are consistently underrepresented in molecular research on autism spectrum disorders (ASD). Yet, Africa’s genetic diversity could reveal novel mechanisms associated with ASD etiology. We review the molecular ASD research from Africa between 2016–2022, highlighting region-specific limitations, opportunities, and areas of progress. We emphasize a need to advance null-hypothesis based molecular studies in Africa, particularly in critically understudied Sub-Saharan African (SSA) populations. Using South Africa as a case study, we show that this geographical disparity is not solely attributable to sociocultural barriers nor to an absence of molecular research infrastructure. We emphasize the importance of interdisciplinary collaboration within SSA and internationally to harness existing infrastructure for the expansion of molecular ASD research in Africa.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Review Journal of Autism and Developmental Disorders PSYCHOLOGY, DEVELOPMENTAL-

CiteScore

8.40

自引率

0.00%

发文量

期刊介绍： The Review Journal of Autism and Developmental Disorders publishes original articles that provide critical reviews of topics across the broad interdisciplinary research fields of autism spectrum disorders. Topics range from basic to applied and include but are not limited to genetics, neuroscience, diagnosis, applied behavior analysis, psychopharmacology, incidence, prevalence, etiology, differential diagnosis, treatment, measurement of treatment effects, education, perception and cognition. Topics across the life span are appropriate. In addition, given the high rates of comorbid conditions, the interface of sleep disorders, feeding problems, motor difficulties, ADHD, anxiety, depression and other disorders with autism spectrum disorders are appropriate. The Journal aims for an international audience as reflected in the editorial board.