{"title":"结直肠癌卵巢转移灶切除术的影响及临床病理分析：日本多中心回顾性研究","authors":"Hiroyasu Kagawa, Yusuke Kinugasa, Tomohiro Yamaguchi, Masayuki Ohue, Kazushige Kawai, Junichiro Hiro, Seiichi Shinji, Hiroaki Nozawa, Yasumitsu Hirano, Koji Komori, Yasumasa Takii, Takeshi Suto, Shunsuke Tsukamoto, Yoshito Akagi, Heita Ozawa, Yuji Toiyama, Kazuhito Minami, Tomoharu Shimizu, Kay Uehara, Kazuhiro Sakamoto, Keita Mori, Kenichi Sugihara, Yoichi Ajioka","doi":"10.1002/ags3.12740","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [<i>P <</i> 0.01] and noncurative resection vs nonresection [<i>P <</i> 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (<i>P <</i> 0.01), bilateral ovarian metastasis (<i>P =</i> 0.01), peritoneal metastasis (<i>P <</i> 0.01), pulmonary metastasis (<i>P =</i> 0.04), liver metastasis (<i>P <</i> 0.01), and remnant of ovarian metastasis (<i>P <</i> 0.01) were statistically significantly different.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.</p>\n </section>\n </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"8 2","pages":"273-283"},"PeriodicalIF":2.9000,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12740","citationCount":"0","resultStr":"{\"title\":\"Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan\",\"authors\":\"Hiroyasu Kagawa, Yusuke Kinugasa, Tomohiro Yamaguchi, Masayuki Ohue, Kazushige Kawai, Junichiro Hiro, Seiichi Shinji, Hiroaki Nozawa, Yasumitsu Hirano, Koji Komori, Yasumasa Takii, Takeshi Suto, Shunsuke Tsukamoto, Yoshito Akagi, Heita Ozawa, Yuji Toiyama, Kazuhito Minami, Tomoharu Shimizu, Kay Uehara, Kazuhiro Sakamoto, Keita Mori, Kenichi Sugihara, Yoichi Ajioka\",\"doi\":\"10.1002/ags3.12740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [<i>P <</i> 0.01] and noncurative resection vs nonresection [<i>P <</i> 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (<i>P <</i> 0.01), bilateral ovarian metastasis (<i>P =</i> 0.01), peritoneal metastasis (<i>P <</i> 0.01), pulmonary metastasis (<i>P =</i> 0.04), liver metastasis (<i>P <</i> 0.01), and remnant of ovarian metastasis (<i>P <</i> 0.01) were statistically significantly different.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.</p>\\n </section>\\n </div>\",\"PeriodicalId\":8030,\"journal\":{\"name\":\"Annals of Gastroenterological Surgery\",\"volume\":\"8 2\",\"pages\":\"273-283\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2023-09-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12740\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Gastroenterological Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ags3.12740\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Gastroenterological Surgery","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ags3.12740","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan
Aim
The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics.
Methods
In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors.
Results
The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [P < 0.01] and noncurative resection vs nonresection [P < 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (P < 0.01), bilateral ovarian metastasis (P = 0.01), peritoneal metastasis (P < 0.01), pulmonary metastasis (P = 0.04), liver metastasis (P < 0.01), and remnant of ovarian metastasis (P < 0.01) were statistically significantly different.
Conclusion
The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.
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