睡眠-觉醒状态下对桥脑柄被盖核的调节

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Sleep and Biological Rhythms Pub Date : 2023-09-26 DOI:10.1007/s41105-023-00489-7

Yiting Luo, Ying Li, Jie Yuan

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引用次数: 0

摘要

摘要:桥脚被盖核(PPTg)在睡眠/清醒状态中起着至关重要的作用。有三种主要的异质神经元参与:胆碱能、谷氨酸能和γ -氨基丁酸能(GABAergic)神经元。然而，胆碱能、谷氨酸能和gaba能PPTg细胞群在调节睡眠-觉醒中的确切作用尚不清楚。最近的研究表明，PPTg的胆碱能、谷氨酸能和氨基丁酸能神经元可能激活主要的唤醒促进核，从而发挥其唤醒作用。本文综述了PPTg各神经元的相关投射通路和功能，特别是PPTg在睡眠-觉醒中的作用机制，为睡眠-觉醒机制的研究提供了新的视角。

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The regulation of the pedunculopontine tegmental nucleus in sleep–wake states

Abstract The pedunculopontine tegmental nucleus (PPTg) plays a vital role in sleep/wake states. There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic, and gamma-aminobutyric acidergic (GABAergic) neurons. However, the precise roles of cholinergic, glutamatergic and GABAergic PPTg cell groups in regulating sleep–wake are unknown. Recent work suggests that the cholinergic, glutamatergic, and GABAergic neurons of the PPTg may activate the main arousal-promoting nucleus, thus exerting their wakefulness effects. We review the related projection pathways and functions of various neurons of the PPTg, especially the mechanisms of the PPTg in sleep–wake, thus providing new perspectives for research of sleep–wake mechanisms.

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来源期刊

Sleep and Biological Rhythms 医学-临床神经学

CiteScore

2.20

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： Sleep and Biological Rhythms is a quarterly peer-reviewed publication dealing with medical treatments relating to sleep. The journal publishies original articles, short papers, commentaries and the occasional reviews. In scope the journal covers mechanisms of sleep and wakefullness from the ranging perspectives of basic science, medicine, dentistry, pharmacology, psychology, engineering, public health and related branches of the social sciences