绿海藻Ulva lactuca:超声辅助提取、结构及细胞毒活性的优化

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-14 DOI:10.1080/07328303.2023.2280560

Thuy T. T. Thanh, Quang V. Ngo, Tai T. Nguyen, Anh N. Nguyen, Thu T. M. Quach, Luong V. Dang, Tam Q. Nguyen, Xuan T. T. Do

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引用次数: 0

摘要

摘要采用超声辅助提取的方法，从绿海藻中提取一种紫檀素。采用响应面法对提取条件进行优化。最佳提取条件为提取温度84.75℃，提取时间30.51 min，料液比60.51 mL/g，得率为22.5%。该化合物由三个双糖组成:→4)-β- d -葡萄糖醛酸(1→4)α- l -鼠李糖-3-硫酸盐(1→，→4)α- l -伊杜醛酸(1→4)α- d -木糖-2-硫酸盐(1→4)α- l -鼠李糖-3-硫酸盐(1→，→4)α- d -木糖-2-硫酸盐(1→4)α- l -鼠李糖-3-硫酸盐(→)。对人肝癌、人乳腺癌、人宫颈癌、人结直肠腺癌和人未分化甲状腺癌等5种人类癌细胞系均有细胞毒活性。关键词:细胞毒活性;结构;超声辅助提取;本研究由越南科技部资助，项目编号为NDT.89.JPN/20。

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Ulvan from green seaweed Ulva lactuca : Optimization of ultrasound-assisted extraction, structure, and cytotoxic activity

AbstractAn ulvan was extracted from green seaweed Ulva lactuca by ultrasound-assisted extraction. The extraction conditions were optimized by response surface methodology. The optimal conditions were extraction temperature at 84.75 °C, extraction time of 30.51 min, solvent to material ratio of 60.51 mL/g to achieve the yield of 22.5%. The ulvan is composed of repeated sequences of three disaccharides: →4)-β-D-Glucuronic acid(1→4)α-L-Rhamnose-3-sulfate(1→, →4)α-L-Iduronic acid(1→4)α-L-Rhamnose-3-sulfate(1→, and →4)α-D-Xylose-2-sulfate(1→4)α-L-Rhamnose-3-sulfate(→. The ulvan showed cytotoxic activities against five human cancer cell lines, including human hepatocellular carcinoma, human breast cancer, human cervical cancer, human colorectal adenocarcinoma and human undifferentiated thyroid carcinomas.Keywords: Cytotoxic activitystructureultrasound-assisted extractionUlva lactucaUlvan Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis research is funded by the Ministry of Science and Technology of Vietnam under project number NDT.89.JPN/20.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.