Zhan Xu, Jialiang Fan, Weiguo Tian, Xin Ji, Yuqian Cui, Qinying Nan, Feifei Sun, Jun Zhang
{"title":"具有单向排湿功能的纤维素基 pH 值响应型 Janus 敷料,用于渗出物管理和糖尿病伤口愈合","authors":"Zhan Xu, Jialiang Fan, Weiguo Tian, Xin Ji, Yuqian Cui, Qinying Nan, Feifei Sun, Jun Zhang","doi":"10.1002/adfm.202307449","DOIUrl":null,"url":null,"abstract":"<p>Diabetic wounds with hyperglycemic tissue exudates and bacterial infections have become a great challenge that seriously delays the healing of diabetic wounds. Therefore, multifunctional dressings for exudate management of diabetic wound are urgently needed. Herein, a smart dressing with rapid moisture-drained and non-adhesive, pH-responsive, and antibacterial capabilities is proposed for exudate management and wound monitoring. The Janus dressing is assembled with an antioxidant, pH-sensitive, and hydrophilic cellulose cover and an antibacterial hydrophobic polycaprolactone bottom layer that directly contacts with the wounds, which can unidirectionally and irreversibly drain the wound exudates and weaken the wet adhesion to the wound. In response to the humoral pH variations (5-9) during the healing process ofdiabetic wounds, the healing process can be in situ monitored according to the distinct pH-responsive colors of the Janus dressing at different healing stages. In vivo assays and histopathological studies suggest that the Janus dressing has a superior pro-healing rate, collagen deposition, and angiogenesis than commercial gauze. Notably, such a mulitfunctional dressing provides real-time wound monitoring simply through a smartphone integrated with Python-RGB programs, which can significantly alleviate the hyperglycemic exudate-flooded environment as an alternative strategy for diabetic wound treatment.</p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cellulose-Based pH-Responsive Janus Dressing with Unidirectional Moisture Drainage for Exudate Management and Diabetic Wounds Healing\",\"authors\":\"Zhan Xu, Jialiang Fan, Weiguo Tian, Xin Ji, Yuqian Cui, Qinying Nan, Feifei Sun, Jun Zhang\",\"doi\":\"10.1002/adfm.202307449\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Diabetic wounds with hyperglycemic tissue exudates and bacterial infections have become a great challenge that seriously delays the healing of diabetic wounds. Therefore, multifunctional dressings for exudate management of diabetic wound are urgently needed. Herein, a smart dressing with rapid moisture-drained and non-adhesive, pH-responsive, and antibacterial capabilities is proposed for exudate management and wound monitoring. The Janus dressing is assembled with an antioxidant, pH-sensitive, and hydrophilic cellulose cover and an antibacterial hydrophobic polycaprolactone bottom layer that directly contacts with the wounds, which can unidirectionally and irreversibly drain the wound exudates and weaken the wet adhesion to the wound. In response to the humoral pH variations (5-9) during the healing process ofdiabetic wounds, the healing process can be in situ monitored according to the distinct pH-responsive colors of the Janus dressing at different healing stages. In vivo assays and histopathological studies suggest that the Janus dressing has a superior pro-healing rate, collagen deposition, and angiogenesis than commercial gauze. Notably, such a mulitfunctional dressing provides real-time wound monitoring simply through a smartphone integrated with Python-RGB programs, which can significantly alleviate the hyperglycemic exudate-flooded environment as an alternative strategy for diabetic wound treatment.</p>\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2023-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202307449\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202307449","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Cellulose-Based pH-Responsive Janus Dressing with Unidirectional Moisture Drainage for Exudate Management and Diabetic Wounds Healing
Diabetic wounds with hyperglycemic tissue exudates and bacterial infections have become a great challenge that seriously delays the healing of diabetic wounds. Therefore, multifunctional dressings for exudate management of diabetic wound are urgently needed. Herein, a smart dressing with rapid moisture-drained and non-adhesive, pH-responsive, and antibacterial capabilities is proposed for exudate management and wound monitoring. The Janus dressing is assembled with an antioxidant, pH-sensitive, and hydrophilic cellulose cover and an antibacterial hydrophobic polycaprolactone bottom layer that directly contacts with the wounds, which can unidirectionally and irreversibly drain the wound exudates and weaken the wet adhesion to the wound. In response to the humoral pH variations (5-9) during the healing process ofdiabetic wounds, the healing process can be in situ monitored according to the distinct pH-responsive colors of the Janus dressing at different healing stages. In vivo assays and histopathological studies suggest that the Janus dressing has a superior pro-healing rate, collagen deposition, and angiogenesis than commercial gauze. Notably, such a mulitfunctional dressing provides real-time wound monitoring simply through a smartphone integrated with Python-RGB programs, which can significantly alleviate the hyperglycemic exudate-flooded environment as an alternative strategy for diabetic wound treatment.
期刊介绍:
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.