支气管哮喘患者的跨学科监测

Corina Eugenia Budin, Gabriela-Paula Pop
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引用次数: 0

摘要

支气管哮喘的特征是气道的慢性炎症,伴有限制空气流动的变异性阻塞,以及由各种刺激引起的支气管过度活跃。哮喘患者最常见的症状是喘息、呼吸困难、咳嗽和胸闷。支气管哮喘具有很高的变异性,这使得其表型对指导治疗非常重要。在最常见的表型中,我们提到过敏性哮喘、非过敏性哮喘、迟发性支气管哮喘、固定气流受限的持续性哮喘以及与肥胖相关的哮喘。彻底的记忆和支气管扩张试验的肺活量测定有助于我们确定支气管哮喘的诊断。服用四次短效支气管扩张剂后,最大每秒呼气量(VEMS)比初始值增加12%和200ml,提示支气管哮喘。ACT问卷用于显示疾病在治疗上是否得到良好控制。暴露于过敏原、超重、胃食管反流病、鼻窦炎、鼻腔息肉病和吸烟是支气管哮喘危象的一些合并症和诱发因素。在治疗方面,哮喘患者的吸入装置含有作为一线治疗的吸入co - ti - co - ste - roids,其中添加了长效β - 2激动剂。为每位患者选择合适的治疗方案是基于五个治疗阶段,这取决于每位患者的症状-病症-病症、哮喘的表型和存在的共病-病症。严重哮喘患者受益于靶向生物治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interdisciplinary monitoring of the patient with bronchial asthma
Bronchial asthma is characterized by chronic inflammation of the airways, associated with variable obstruction that li­mits air flow, and bronchial hyperactivity caused by va­rious sti­muli. The most common symptoms present in asth­ma­tic peo­ple are wheezing, dyspnea, cough and chest con­stric­tion. Bronch­ial asthma has a high variability, which makes its phenotyping very important for guiding treat­ment. Among the most common phenotypes, we mention allergic asth­ma, nonallergic asthma, late-onset bronchial asthma, per­sis­tent asthma with a fixed limitation of airflow, and asth­ma associated with obesity. A thorough anamnesis and performing spirometry with bronchodilator test help us to establish the diagnosis of bronchial asthma. The increase in the maximum expiratory volume per second (VEMS) by 12% and 200 ml from the initial value after taking four short-acting bronchodilator puffs is suggestive of bronchial asth­ma. The ACT questionnaire is used to show whether the di­sease is well controlled therapeutically. Exposure to allergens, over­weight, gastroesophageal reflux disease, rhinosinusitis, na­sal polyposis and smoking are some of the comorbidities and trig­­gers of bronchial asthma crisis. In terms of treatment, asth­matic patients have inhaled de­vices that contain as the first line of treatment inhaled cor­ti­co­ste­roids to which a long-acting beta2-agonist is added. Choosing the right the­ra­py for each patient is made on the basis of five stages of treatment, depending on the symp­to­ma­to­logy of each in­di­vi­dual patient, the phenotype of asth­ma and the co­mor­bi­di­ties present. Patients with severe asth­ma benefit from tar­ge­ted biological therapy.
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