影响咪康唑体外释放的因素

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
FatimaJalal Al_Gawhari
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引用次数: 0

摘要

进行本研究的目的是通过眼基凝胶(OBGs)制剂延长咪康唑在眼部作用部位的释放。应采用不同浓度的不同胶凝剂研究影响OBG释放的配方因素,以改善其滞留和停留时间,以响应延长的释放。以卡波醇940、果胶、海藻酸钠、poloxomer 407和聚甲基丙烯酸为原料,分别以0.5%、1%和1.5% w/v的质量分数制备了该配方。加入1%羟丙基甲基纤维素E5 (HPMC E5)作为增稠剂/增粘剂。与参比药相比,含有卡波波尔940、果胶和1.5% w/v海藻酸钠的制剂在粘度、胶凝能力和延长释放7 h方面有明显改善。总体上,海藻酸钠与HPMC E5形成原位凝胶,与其他聚合物相比,其释放时间可达12 h。释放的咪康唑OBGs受到两个因素的极大影响包括胶凝能力和粘度builder。这项研究的新颖之处在于支持通过角膜作为眼睛的重要关键来输送眼部药物,而不是依赖于使用口服或父母给药的内部血液供应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors affecting on in vitro release of miconazole from in situ ocular gel
The reason for conducting this study is to prolong release of miconazole in the ocular site of action by ocular-based gels (OBGs) formulations. The formulation factors affecting on the release from OBG should be studied using various gelling agents in various concentrations to achieve the improvement in retention and residence time in response to prolonged release. In this study, the formulations were prepared using carbopol 940, pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and 1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling capacity, and extended release for 7 h in comparison with the reference drug. Overall, the release showed that the sodium alginate with HPMC E5 form in situ gel which had longer time of release reach to 12 h compared with other polymers. the release of miconazole from the OBGs affected significantly by two factors includes gelling capacity and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs through a cornea as an important key of the eye instead of dependence on an internal blood supply using an oral or a parental administration.
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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