一项针对7岁以下早产儿补充DHA的随机试验的亚组分析:妊娠<29周的婴儿会发生什么?

IF 3
JF Gould , JM Bednarz , TR Sullivan , AJ McPhee , RA Gibson , M Makrides
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引用次数: 0

摘要

最近的一项试验表明,在妊娠29周出生的婴儿中补充高剂量二十二碳六烯酸(高dha)可提高其5岁修正年龄时的智商(IQ)。然而,这一发现并没有在DHA的其他试验中被发现,这些试验要么没有测量智商,要么包括更成熟的婴儿。我们分析了204名29周出生的婴儿亚组,这些婴儿来自我们早期的高dha(总脂肪酸约1%)或标准dha(总脂肪酸约0.3%)的随机试验。参与者在18个月大时接受认知评估,在7岁时接受智商和行为评估。在平均认知、智商或行为得分方面,没有发现组间差异。在18个月时,高dha组中18.8%的儿童的认知评分为85分,而标准dha组中31.1%的儿童的认知评分为85分,但在7岁时没有差异。尽管这项研究的亚组分析能力不足,但它对妊娠29周出生的婴儿需要补充DHA的建议提供了有限的支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subgroup analyses of a randomized trial of DHA supplementation for infants born preterm with assessments of cognitive development up to 7-years of age: What happens in infants born <29 weeks’ gestation?

A recent trial showed that high-dose docosahexaenoic acid (high-DHA) supplementation of infants born <29 weeks’ gestation improves intelligence quotient (IQ) at five years’ corrected age. However, this finding has not been detected by other trials of DHA, which either did not measure IQ or included more mature infants. We analyzed the subgroup of 204 infants born <29 weeks’ from our earlier randomized trial of high-DHA (∼1 % total fatty acids) or standard-DHA (∼ 0.3 % total fatty acids). Participants were assessed for cognition at 18 months, and IQ and behavior at seven years’ corrected age. No group differences were detected for mean cognitive, IQ or behavior scores. At 18 months, 18.8 % of children in the high-DHA group had a cognitive score <85, compared with 31.1 % of children in the standard-DHA group, but at seven years there was no difference. Although an underpowered post-hoc subgroup analysis, this study provides limited support to recommendations that infants born <29 weeks’ gestation require supplemental DHA.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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0.00%
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0
审稿时长
64 days
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