{"title":"钠稳态和信号传导:星形胶质细胞功能的核心和枢纽","authors":"Christine R. Rose , Alexej Verkhratsky","doi":"10.1016/j.ceca.2023.102817","DOIUrl":null,"url":null,"abstract":"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sodium homeostasis and signalling: The core and the hub of astrocyte function\",\"authors\":\"Christine R. Rose , Alexej Verkhratsky\",\"doi\":\"10.1016/j.ceca.2023.102817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>\",\"PeriodicalId\":9678,\"journal\":{\"name\":\"Cell calcium\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell calcium\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143416023001288\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell calcium","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143416023001288","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Sodium homeostasis and signalling: The core and the hub of astrocyte function
Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.
期刊介绍:
Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include:
Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling
Influence of calcium regulation in affecting health and disease outcomes