钠稳态和信号传导:星形胶质细胞功能的核心和枢纽

IF 4.3 2区 生物学 Q2 CELL BIOLOGY
Christine R. Rose , Alexej Verkhratsky
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引用次数: 0

摘要

神经元活动和神经化学刺激引发星形胶质细胞胞质Na+离子浓度的时空变化。这些变化构成Na+信号传导的底物,是星形细胞兴奋性的基础。星形胶质细胞Na+信号是由Na+通过神经递质(主要是谷氨酸转运体)内流并通过阳离子通道产生的;而Na+瞬态的恢复主要是由细胞质Na+/K+ atp酶介导的。星形胶质细胞Na+信号调节对星形胶质细胞稳态功能至关重要的质浆转运蛋白的活性,从而在神经元活动和星形胶质细胞支持之间提供实时协调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sodium homeostasis and signalling: The core and the hub of astrocyte function

Sodium homeostasis and signalling: The core and the hub of astrocyte function

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.

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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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