钠稳态和信号传导:星形胶质细胞功能的核心和枢纽

IF 4.3 2区 生物学 Q2 CELL BIOLOGY
Christine R. Rose , Alexej Verkhratsky
{"title":"钠稳态和信号传导:星形胶质细胞功能的核心和枢纽","authors":"Christine R. Rose ,&nbsp;Alexej Verkhratsky","doi":"10.1016/j.ceca.2023.102817","DOIUrl":null,"url":null,"abstract":"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sodium homeostasis and signalling: The core and the hub of astrocyte function\",\"authors\":\"Christine R. Rose ,&nbsp;Alexej Verkhratsky\",\"doi\":\"10.1016/j.ceca.2023.102817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>\",\"PeriodicalId\":9678,\"journal\":{\"name\":\"Cell calcium\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell calcium\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143416023001288\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell calcium","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143416023001288","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

神经元活动和神经化学刺激引发星形胶质细胞胞质Na+离子浓度的时空变化。这些变化构成Na+信号传导的底物,是星形细胞兴奋性的基础。星形胶质细胞Na+信号是由Na+通过神经递质(主要是谷氨酸转运体)内流并通过阳离子通道产生的;而Na+瞬态的恢复主要是由细胞质Na+/K+ atp酶介导的。星形胶质细胞Na+信号调节对星形胶质细胞稳态功能至关重要的质浆转运蛋白的活性,从而在神经元活动和星形胶质细胞支持之间提供实时协调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sodium homeostasis and signalling: The core and the hub of astrocyte function

Sodium homeostasis and signalling: The core and the hub of astrocyte function

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信