健康女性疼痛敏感性的年龄差异及外用利多卡因对舌部的影响。

IF 1.9 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of oral science Pub Date : 2024-01-16 Epub Date: 2023-11-15 DOI:10.2334/josnusd.23-0167
Ichiro Okayasu, Mizuki Tachi, Takao Ayuse, Hiroyuki Wake, Osamu Komiyama, Antoon De Laat
{"title":"健康女性疼痛敏感性的年龄差异及外用利多卡因对舌部的影响。","authors":"Ichiro Okayasu, Mizuki Tachi, Takao Ayuse, Hiroyuki Wake, Osamu Komiyama, Antoon De Laat","doi":"10.2334/josnusd.23-0167","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To assess the sensitivity and the effect of topical lidocaine on the tongue by quantitative sensory testing, comparing healthy middle-aged female subjects with healthy young female subjects.</p><p><strong>Methods: </strong>Sixteen healthy female subjects including eight in their fifties and eight in their twenties participated. They participated in two sessions at a 2-week interval in randomized order: lidocaine (experimental session) or placebo gel (placebo session) was applied on the tongue tip for 5min. The following parameters were taken on the tongue tip before and after application of the gel in each session: tactile detection threshold (TDT), filament-prick pain detection threshold (FPT), and numerical rating scale (NRS).</p><p><strong>Results: </strong>An increase of both TDT and FPT and a decrease of NRS were found after lidocaine application in both middle-aged and young female subjects. In the elder females, an increase of TDT, FPT, and NRS was also found after placebo gel application. However, the changes were not statistically significant, except for FPT in middle-aged subjects.</p><p><strong>Conclusion: </strong>The reactions found after lidocaine application in middle-aged female subjects could be due to habituation as well as to the post-application effect of placebo gel. Placebo-induced changes appeared more pronounced in the elder females.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age differences in pain sensitivity and effect of topical lidocaine on the tongue in healthy female subjects.\",\"authors\":\"Ichiro Okayasu, Mizuki Tachi, Takao Ayuse, Hiroyuki Wake, Osamu Komiyama, Antoon De Laat\",\"doi\":\"10.2334/josnusd.23-0167\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To assess the sensitivity and the effect of topical lidocaine on the tongue by quantitative sensory testing, comparing healthy middle-aged female subjects with healthy young female subjects.</p><p><strong>Methods: </strong>Sixteen healthy female subjects including eight in their fifties and eight in their twenties participated. They participated in two sessions at a 2-week interval in randomized order: lidocaine (experimental session) or placebo gel (placebo session) was applied on the tongue tip for 5min. The following parameters were taken on the tongue tip before and after application of the gel in each session: tactile detection threshold (TDT), filament-prick pain detection threshold (FPT), and numerical rating scale (NRS).</p><p><strong>Results: </strong>An increase of both TDT and FPT and a decrease of NRS were found after lidocaine application in both middle-aged and young female subjects. In the elder females, an increase of TDT, FPT, and NRS was also found after placebo gel application. However, the changes were not statistically significant, except for FPT in middle-aged subjects.</p><p><strong>Conclusion: </strong>The reactions found after lidocaine application in middle-aged female subjects could be due to habituation as well as to the post-application effect of placebo gel. Placebo-induced changes appeared more pronounced in the elder females.</p>\",\"PeriodicalId\":16646,\"journal\":{\"name\":\"Journal of oral science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral science\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.2334/josnusd.23-0167\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/11/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral science","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.2334/josnusd.23-0167","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

摘要

目的:通过定量感觉试验,比较健康中年女性和健康青年女性外用利多卡因对舌部的敏感性和影响。方法:健康女性16例,其中50岁8例,20岁8例。他们按随机顺序每隔2周参加两个阶段:利多卡因(实验阶段)或安慰剂凝胶(安慰剂阶段)在舌尖上涂抹5分钟。在每次使用凝胶前后对舌尖进行以下参数测量:触觉检测阈值(TDT)、细丝刺痛检测阈值(FPT)和数值评定量表(NRS)。结果:中青年女性应用利多卡因后TDT、FPT均升高,NRS下降。在老年女性中,安慰剂凝胶应用后,TDT、FPT和NRS也有所增加。然而,除了中年受试者的FPT外,这些变化没有统计学意义。结论:中年女性受试者使用利多卡因后出现的反应可能是由于适应所致,也可能是安慰剂凝胶的作用所致。安慰剂引起的变化在老年女性中更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age differences in pain sensitivity and effect of topical lidocaine on the tongue in healthy female subjects.

Purpose: To assess the sensitivity and the effect of topical lidocaine on the tongue by quantitative sensory testing, comparing healthy middle-aged female subjects with healthy young female subjects.

Methods: Sixteen healthy female subjects including eight in their fifties and eight in their twenties participated. They participated in two sessions at a 2-week interval in randomized order: lidocaine (experimental session) or placebo gel (placebo session) was applied on the tongue tip for 5min. The following parameters were taken on the tongue tip before and after application of the gel in each session: tactile detection threshold (TDT), filament-prick pain detection threshold (FPT), and numerical rating scale (NRS).

Results: An increase of both TDT and FPT and a decrease of NRS were found after lidocaine application in both middle-aged and young female subjects. In the elder females, an increase of TDT, FPT, and NRS was also found after placebo gel application. However, the changes were not statistically significant, except for FPT in middle-aged subjects.

Conclusion: The reactions found after lidocaine application in middle-aged female subjects could be due to habituation as well as to the post-application effect of placebo gel. Placebo-induced changes appeared more pronounced in the elder females.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of oral science
Journal of oral science DENTISTRY, ORAL SURGERY & MEDICINE-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
3.80
自引率
0.00%
发文量
58
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信