Laetiporus sulphureus Affects Migration and Superoxide Anion Radical Levels in HeLa Cervical Cancer Cells

1 – Abstract: Cervical cancer is the fourth most common female malignancy worldwide. Treatment of cancer cells with metastatic potential is an important issue in cancer therapy. In this study, we in-vestigated edible and medicinal mushroom Laetiporus sulphureus (Bull.) Murrill with known bio-logical properties for human health. Two selected concentrations (10 and 50 µg/mL) of ethanolic extract of L. sulphureus were used to determine the level of superoxide anion radical (NBT test) and migratory potential (Wound healing test) on cervical cancer cell line (HeLa). Effects were measured after 24 and 72 h. The extract induced an acute prooxidative effect on HeLa cells, with a significant reduction in migratory potential of these cells in both tested concentrations. A higher concentration (50 µg/mL) has a slightly stronger antimigratory activity. Laetiporus sulphureus is a very important source of biologically active substances and should be reconsidered for development of promising anticancer therapeutics.