口服高剂量氯化镁对大鼠布氏锥虫和刚果锥虫感染致病性的影响

Tropical veterinarian Pub Date : 2004-04-23 DOI:10.4314/TV.V21I3.4537

T. Egbe-Nwiyi, S. Nwaosu, Rd Tsuya

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引用次数: 6

摘要

采用体重200 ~ 240 g的健康成年雄性白化大鼠80只，评价高剂量口服氯化镁(100mg/kg体重)对布氏布氏结核杆菌(Basa株)或刚果热结核杆菌(Gboko株)感染致病性的影响。实验共进行2项研究，将大鼠分为4组，每组10只大鼠(每组);A组(未感染，未补充对照)，B组(未感染，并补充氯化镁)，C组(布氏布氏杆菌或刚果锥虫感染，1 × 10 6锥虫并补充)，D组(布氏布氏布氏杆菌或刚果锥虫感染，1 × 10 6锥虫，未补充)。B组和C组每只大鼠在感染前和感染过程中每天灌胃约0.2ml MgCl2，持续10天。专利前期和存活时间较短(P关键词:氯化镁;补充;锥虫;致病性;老鼠。太。兽医。Vol. 21:(3) 152-159 (2003)

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The effect of high oral magnesium chloride supplementation on the pathogenicity of Trypanosoma brucei brucei and T. congolense infections in rats

Eighty healthy adult albino rats of both sex weighing 200-240 grams were used to assess the effect of high oral Magnesium chloride (100mg/kg body weight) supplementation on the pathogenicity of T. b. brucei (Basa strain) or T, congolense (Gboko strain) infections. Two studies were carried out and the rats were divided into 4 groups of 10 rats each (per study) namely; Group A (uninfected, unsupplemented control), Group B (uninfected and supplemented with Magnesium chloride), Group C (T.b. brucei or T. congolense infected, 1x10 6 trypanosomes and supplemented), Group D (T.b. brucei or T, congolense infected, 1x10 6 trypanosomes and unsupplemented). Each rat in groups B and C received approximately 0.2ml of MgCl2 intragastrically daily for 10 days before and during the course of the infection. The prepatent period and survival times were shorter (P Key words: Magnesium chloride; Supplementation; Trypanosomes; Pathogenicity; Rats. Trop. Vet. Vol. 21: (3) 152-159 (2003)

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Tropical veterinarian

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