SARS-CoV-2特异性抗原检测纳米生物平台的研制

2022 IEEE International Conference on Design & Test of Integrated Micro & Nano-Systems (DTS) Pub Date : 2022-06-06 DOI:10.1109/DTS55284.2022.9809866

Asma El Golli, Simone Cavalera, F. Di Nardo, L. Anfossi, C. Dridi

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引用次数: 0

摘要

侧流免疫分析法(LFIA)已被用于开发快速、低成本和相对简单的新冠肺炎诊断设备。该方法报道了使用金纳米颗粒标记的抗体同时检测核衣壳蛋白和Spike蛋白。在大量鼻咽拭子中考虑与传统分析方法(PCR)获得的结果进行比较;阳性个体48份，阴性个体26份。本研究为开发一种更高效的SARS-Co V-2抗原检测方法作为一种低成本、快速的预筛选工具提供了基础。

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Development of a nano-bioplatform for SARS-CoV-2 specific antigens detection

Lateral Flow Immunoassay (LFIA) has been employed for the development of rapid, low-cost, and relatively simple devices for Covid-19 diagnosis. The proposed approach reports the use of the antibody labeled by Gold nanoparticles for the simultaneous detection of Nucleocapsid protein and Spike protein. A comparison with the results obtained by conventional analytical methods (PCR) has been considered in a significant number of nasopharyngeal swabs; 48 and 26 samples from positive and negative individuals respectively. This research provides the basis for the development of a more efficient antigenic test for SARS-Co V-2 detection as a low-cost and quick pre-screening tool.

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2022 IEEE International Conference on Design & Test of Integrated Micro & Nano-Systems (DTS)

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