Tropomyosins of the helminthes: sensitization and association with allergic pathology

The growth of the prevalence of allergic diseases has been a driver for the development of new technologies: over the past two decades, significant progress in biochemistry and molecular allergology has contributed to the study of the structure of allergens and the development of component-resolved diagnostics. In particular, clinically significant families of allergens have been identified, including tropomyosin, which can cause a wide range of cross-IgE-mediated reactions. One of the risk factors for the sensitization development are helminthiases, which are common in different regions, there forein the population of endemic areas. The global prevalence of helminthiasis remains high: it is estimated that 1.5 billion people worldwide are chronically infected with at least one helminth. The purpose of this review is to analyze current studies aimed at determining the relationship between helminth infections and the development of sensitization to helminth tropomyosin and the clinical course of allergic diseases. Methods: Analysis of scientific publications described the relationship between helminths tropomyosin and the development of allergic diseases and sensitization in patients with parasitic infection. We used the PubMed database for the review. The review presents original articles published for a period from January 1, 2000 to December 31, 2021