Effective nano Cyclodextrin-TKIs drug delivery for cancer therapy

Nanotechnology-based studies pursuing the innovative cancer treatment methods, particularly using drug delivery systems, have significantly increased over the past few years. Some of the impacts of using such systems include the increased cytotoxic activity of drugs, reduced unwanted side effects, and a more stable and controlled release of drugs. Particularly using the targeted delivery systems with helping novel nanocarriers made it possible to kill cancer cells specifically. Meanwhile, Cyclodextrins were known as natural cyclic oligosaccharides which serve the intended purposes. Many cancer researchers were interested in them due to the multiple advantages of a variety of materials utilized as nanocarriers for medication delivery. Regarding their unique structure, they can benefit hydrophobic and hydrophilic drugs. On the other hand, tyrosine kinase inhibitors, with their properties to inhibit the growth of cancer cells, are the valuable drugs of choice for various types of cancer. In this regard, cyclodextrins were used as nano-drug delivery systems to transport tyrosine kinase inhibitors in recent studies by researchers. In this review, some recent medical applications of cyclodextrin-based nanocarriers for the delivery of tyrosine kinase inhibitors and the synthesis methods of cyclodextrin-based compounds have been discussed, and the advantages and disadvantages of using cyclodextrin along with tyrosine kinase inhibitors in the treatment of various cancers were mentioned.