吲哚美辛对肾功能不全大鼠生命预后及体内平衡的影响。

Zeitschrift fur Urologie und Nephrologie Pub Date : 1990-09-01

B Hortian, P W Wüstenberg, R Wenk

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引用次数: 0

摘要

再次评价了前列腺素合成抑制剂吲哚美辛对残留肾单位致病性超滤的药物治疗调节作用。对近交系wistar大鼠进行的实验研究，包括低剂量的吲哚美辛1.5 mg/kg BW，肾实质明显减少(80%)和食物蛋白质含量增加40%，确实显示了已知的结果:吲哚美辛可能损害严重肾损伤的重要预后。

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[Effect of indomethacin on the vital prognosis and homeostasis of rats with kidney insufficiency].

The medicamentous-therapeutic modulation of pathogenic hyperfiltration of residual nephrons by the prostaglandin synthesis inhibitor indomethacin was evaluated again. The experimental study of inbred wistar rats including a low indomethacin dosage of 1.5 mg/kg BW, a strong reduction of renal parenchyma (80%) and an increased food protein content of 40% did show the known results: indomethacin may impair the vital prognosis of severe renal injury.

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Zeitschrift fur Urologie und Nephrologie

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