eHealth system with ISFET-based immunosensor for heart failure biomarker detection in saliva

Heart failure is a chronic condition that sorely affects the worldwide population with huge health and economic costs. The purpose of this research is to present an ISFET-based immunosensor sensible to low concentrations of TNF-α biomarker in saliva, a protein related with the severity state of heart failure patients, together with a proof-of-concept IoT-based user-centered health ecosystem, aiming to reduce hospital-centered associated costs and improving patient monitoring. The immunosensor presents a low limit of detection of 5pg/mL, with good cross-selectivity versus other saliva biomarkers, using a low cost and short run-time detection technique, optimal for its implementation in a distributed monitoring system.