Importance of controlling obesity and associated immune response changes in prevention and treatment of cancer–with plant therapies of help

like inflammation in general in obesity ,hypothalamic inflammation ,GIT inflammation ,and others which have influenced development of medical treatments having edge over bariatric surgery but have not been successful in getting any stable medical therapy that can be used for long.6–10 Natural Killer (NK)cells represent one of the populations of the lymphocytes belonging to the innate immune system. By definition they are the cells that have the capacity to kill infected or transformed cells without needing any previous activation. Besides their cytotoxic capacity, they can also produce inflammatory cytokines like interferon gamma (IFNγ) and thus are a key part of early immune responses. In view of these abilities which make them stand out, these NKcells is very important part for host protection, mainly antitumor and antiviral immunity. In the last 10years, a lot of work has been done to study the effect of obesity on NKcell biology, giving a full briefing of systemic dysregulation of NKcell functions. Recently various publications have examined the role of NKcells in the homeostasis of adipose tissue (AT) and the aetopathogenesis of obesity. Worldwide, cancer has become a leading cause of mortality, with 7.6 million deaths occurring yearly.11 A report from centre of diseases control (CDC)in United States have pointed to obesity being responsible for 40% of cases of cancer ,that accounts for 630,000 diagnosis in 2014 alone.12 This study is similar to what has been found all over the world.13 Multifactorial changes like hormones, cytokines and immunity observed in cancers related to obesity. Obesity is related to increased insulin levels that further promote the development of some obesity related cancers like colorectal, pancreatic, liver and endometrial.14–16 Various studies have also picked up links with leptin, an adipokine levels that are raised in obese children and adults and cancer. Most researchers trying to study leptin in relation to obesity have mainly concentrated on breast cancer, in which case leptin has the ability to directly stimulate breast cancer cells proliferation.17 Also the other part common to obesity related cancer occurring is the chronic inflammation present in obesity.18 Various studies have emphasized on the interaction between inflammation and cancer developing as exemplified by colonic carcinogenesis in patients suffering from inflammatory bowel disease.19 Thus we have reviewed the role of NK cells in how the Alteration in Natural Killer (NK)cell Function in Obesity, correlates with the development of comorbidities like cancer and type 2 diabetes.20