{"title":"2-芳香族取代1,3-泰唑烷衍生物的设计、合成及抗菌活性研究","authors":"Krishna Reddy Gayam, Senthil M Palaniappan","doi":"10.46624/ajphr.2019.v7.i8.003","DOIUrl":null,"url":null,"abstract":"A series of N-{[2-(substituted methylidene)hydrazinyl](methylsulfanyl)methyl}-2-substituted1,3-thiazolidine-4-carboxamide derivative were synthesized. The synthesized compounds were characterized by IR, NMR, Mass spectral data. The synthesized compounds were screened for their antifungal and antibacterial activity against pathogenic fungus and bacteria. Compounds TS-2, TS-4 and TS-9 exhibited good antibacterial and antifungal activity against the tested microorganisms, and the rest of the molecules shows good to moderate activity.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"141 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Design, Synthesis and Antimicrobial Activity of 2-Aromatic Substituted-1,3-Thaizolidine Derivatives\",\"authors\":\"Krishna Reddy Gayam, Senthil M Palaniappan\",\"doi\":\"10.46624/ajphr.2019.v7.i8.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A series of N-{[2-(substituted methylidene)hydrazinyl](methylsulfanyl)methyl}-2-substituted1,3-thiazolidine-4-carboxamide derivative were synthesized. The synthesized compounds were characterized by IR, NMR, Mass spectral data. The synthesized compounds were screened for their antifungal and antibacterial activity against pathogenic fungus and bacteria. Compounds TS-2, TS-4 and TS-9 exhibited good antibacterial and antifungal activity against the tested microorganisms, and the rest of the molecules shows good to moderate activity.\",\"PeriodicalId\":233230,\"journal\":{\"name\":\"American Journal of Pharmacy And Health Research\",\"volume\":\"141 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Pharmacy And Health Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46624/ajphr.2019.v7.i8.003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pharmacy And Health Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46624/ajphr.2019.v7.i8.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Design, Synthesis and Antimicrobial Activity of 2-Aromatic Substituted-1,3-Thaizolidine Derivatives
A series of N-{[2-(substituted methylidene)hydrazinyl](methylsulfanyl)methyl}-2-substituted1,3-thiazolidine-4-carboxamide derivative were synthesized. The synthesized compounds were characterized by IR, NMR, Mass spectral data. The synthesized compounds were screened for their antifungal and antibacterial activity against pathogenic fungus and bacteria. Compounds TS-2, TS-4 and TS-9 exhibited good antibacterial and antifungal activity against the tested microorganisms, and the rest of the molecules shows good to moderate activity.
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