半乳糖凝集素-1在溃疡性结肠炎伴伴代谢综合征中的调节作用

Kemal Corovic, B. Stojanovic, Andjela Petrović, Isidora Stanisavljević, V. Marić, N. Zdravković, Marina Z Jovanovic
{"title":"半乳糖凝集素-1在溃疡性结肠炎伴伴代谢综合征中的调节作用","authors":"Kemal Corovic, B. Stojanovic, Andjela Petrović, Isidora Stanisavljević, V. Marić, N. Zdravković, Marina Z Jovanovic","doi":"10.2478/eabr-2023-0006","DOIUrl":null,"url":null,"abstract":"Abstract Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.","PeriodicalId":104738,"journal":{"name":"Experimental and Applied Biomedical Research (EABR)","volume":"74 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome\",\"authors\":\"Kemal Corovic, B. Stojanovic, Andjela Petrović, Isidora Stanisavljević, V. Marić, N. Zdravković, Marina Z Jovanovic\",\"doi\":\"10.2478/eabr-2023-0006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.\",\"PeriodicalId\":104738,\"journal\":{\"name\":\"Experimental and Applied Biomedical Research (EABR)\",\"volume\":\"74 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and Applied Biomedical Research (EABR)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/eabr-2023-0006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and Applied Biomedical Research (EABR)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/eabr-2023-0006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

代谢综合征(MetS)和溃疡性结肠炎(UC)是一种以慢性、低度炎症为特征的普遍健康状况。半乳糖凝集素-1 (Gal-1)是一种主要由脂肪组织分泌的免疫调节肽,可能在缓解这些疾病中发挥关键作用。这项横断面研究探讨了75名新诊断为UC的患者中Gal-1在met和UC中的作用。与没有MetS的人相比,MetS亚组显示出更高的粪便Gal-1水平。此外,在这些受试者中,Gal-1表现出优于促炎细胞因子的优势,包括TNF-α、IL-6和IL-17。这些发现强调了Gal-1在UC和MetS的病理生理学中的潜在参与,将其作为这些疾病的有前途的诊断生物标志物和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome
Abstract Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.60
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信