Formation features of nonspecific pathomorphological changes in liver tissue during tumor processes (experimental study)

The study is due to an increase in nonspecific complications in oncological diseases. The research purpose is to study in experiment the features of the formation of nonspecific pathomorphological changes in liver tissue during tumor processes. Research objectives: to simulate toxic hepatitis on the tumor line of mice, to study the effect of the tumor process on pathomorphological changes in the liver with its toxic lesion, to study the effect of a tumor on pathomorphological changes in the liver when using methotrexate, to conduct a comparative analysis of the results and identify the features of the formation of nonspecific changes in liver tissue. Materials and methods. We conduct the study on mice of the Balb/c line. The work was carried out according to the recommendations set out by the Ministry of Health of the USSR no. 755 of August 12, 1977 and the Helsinki Declaration. We form a control group, a comparison group and an experimental group. In the comparison groups, carbon tetrachloride 0.1 ml of 40 % solution and methotrexate at a dosage of 0.2 mg were administered intraperitoneally to animals. The experimental group included animals with formed malignant tumors. Main results. Pathomorphological changes indicate the progression of nonspecific necrobiotic, cholestatic, inflammatory and microcirculatory processes under the influence of a hepatotropic agent. When using cytostatics, necrobiotic, cholestatic and microcirculatory changes progressed without a cellular reaction. Conclusion. The revealed pathomorphological features in the liver tissue indicate the pathogenetic significance of toxic liver damage leading to the progression of liver failure in tumor processes.