临床可解释心律失常分类的运行时间验证

Alex Baird, Srinivas Pinisetty, Nathan Allen, Nitish D. Patel, P. Roop
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引用次数: 0

摘要

心律失常的自动检测是对抗心血管疾病及其相关人类影响的重要工具。这种检测必须既准确又及时,以便能够在短时间内实施干预措施。传统上,这种方法使用了无法解释的黑盒实现,因此在临床可解释性方面使用有限。此外,这些实现可能需要在患者之间进行额外的培训,或者处理时间长,不适合进行实时分类。为了解决这个问题,我们开发了一套正式的基于定时自动机的策略,根据心电图(ECG)特征捕获三种常见的心律失常:室性早搏、室性心动过速和房颤。我们综合了这些策略的运行时验证监视器,并将它们与现有的临床ECG数据库一起运行,以评估其有效性。该方法显示出与现有黑盒工作相当的结果,准确率在90%到96%之间,同时仍然是可解释的和临床可解释的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Runtime Verification for Clinically Interpretable Arrhythmia Classification
Automatic detection of cardiac arrhythmia is an important tool in the fight against cardiovascular diseases and their associated human impacts. Such detection needs to be both accurate and timely, in order to allow for interventions to be administered within short time frames. Traditionally, such approaches have used black box implementations which are not explainable and hence have limited use in terms of clinical interpretability. Additionally, these implementations may either require additional training between patients, or have processing times which make them unsuitable for real-time classification. To address this, we develop a set of formal Timed Automaton-based policies that capture three common arrhythmia, Premature Ventricular Contraction, Ventricular Tachycardia, and Atrial Fibrilation, in terms of Electrocardiogram (ECG) features. We synthesise Runtime Verification monitors for each of these policies, and run them alongside existing clinical ECG databases to evaluate their efficacy. This approach shows comparable results to existing black box work with accuracies ranging from 90 % to 96 % while still being both explainable and clinically interpretable.
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