In Vitro Anti-Inflammatory Activities of Red Gemor (Nothaphoebe cf Umbelliflora)

Gemor (Nothaphoebe cf umbelliflora) is a tree species that found naturally in swampy forest of Sumatra and Kalimantan, Indonesia. The anti-inflammation activity of red gemor plant parts have not been investigated, therefore many study should be performed. Thus our study aimed to investigate the anti-inflammation effect of different parts of red gemor. Phytochemical analysis of diffrent parts of red gemor extracts revealed the presence of various biochemical compounds such as alkaloids, flavonoids, phenolic compounds, triterpenoids and steroid. The antiinflammatory activities was determined by inhibition protein denaturation method. Result of this study revealed there is inhibitory action on protein denaturation. The percentage inhibition varied from 20,154 to 71,667 for highest concentration to the lowest concentration. The IC50 was found to be 60 for twig, 47,8 for bark, and 116,2 for leaves of red gemor. To determined which one of the phytochemical constituent in diffrent parts of red gemor are most influence in anti-inflammation activity, we used linear correlation between IC 50 with alkaloid and flavonid content in different parts of red gemor. The result suggest that flavonoid are the most influence to protein denaturation (R = 0,9927). The results of the present study suggest that the diffrent parts of red gemor have antiinflammation activity. The anti-inflammation activity of different parts of red gemor due to the phytochemical constituents content in different parts of red gemor, such as flavonoid and alkaloid.