Bpd-Ma介导脊柱骨转移的PDT:确定PDT阈值

2019 Photonics North (PN) Pub Date : 2019-05-01 DOI:10.1109/PN.2019.8819594

Dallis Ferguson, William Lo, Daniel Molenhuis, L. Lilge, Fynn Schwiegelshohn, Vaughn Betz, C. Whyne, M. Akens

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引用次数: 0

摘要

脊柱骨转移常表现为溶骨和成骨细胞疾病的弥漫性结合。光动力疗法(PDT)是一种微创疗法，已被证明可以局部消融骨性脊柱内的癌细胞。为了优化患者特异性治疗方案并确保关键神经结构的安全，必须了解异质组织对PDT的反应。这项工作利用苯并卟啉衍生物单酸(BPD-MA)光敏剂得出脊髓PDT阈值。

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Bpd-Ma Mediated PDT of Spinal Bone Metastases: Determining PDT Threshold Values

Spinal bone metastases often present as a diffuse combination of osteolytic and osteoblastic disease. Photodynamic therapy (PDT) is a minimally invasive therapy that has been shown to locally ablate cancer cells within the bony spine. To optimize patient-specific treatment protocols and ensure safety of critical neural structures, the responsivities of the heterogenous tissues to PDT must be known. This work derives a PDT threshold value for the spinal cord using a benzoporphyrin derivative monoacid (BPD-MA) photosensitizer.

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2019 Photonics North (PN)

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